Table 1 Schedule and summary of the comprehensive behavioral analysis of Glra4 mutant mice
From: Comprehensive behavioral analyses of mice with a glycine receptor alpha 4 deficiency
Order | Test | Age* (w) | Â Figures | Phenotype of Glra4 mutant mice |
|---|---|---|---|---|
1 | General health and neurologic screening | 13 | Additional file 3: Fig. S1 | NS |
2 | Light–dark Transition test | 13 | Fig. 4 | NS |
3 | Open field test | 14 | Fig. 4 | NS |
4 | Elevated plus-maze test | 14 | Fig. 4 | ↑ anxiety-like behavior |
5 | Hot plate test | 14 | Additional file 3: Fig. S1 | NS |
6 | Social interaction test | 15 | Fig. 6 | NS |
7 | Rotarod test | 15 | Additional file 3:Â Fig. S1 | NS |
8 | Three-chambered social interaction test | 15 | NS | |
9 | Startle response/Prepulse inhibition test | 16 | Fig. 5 | ↓ and delayed startle response |
10 | Porsolt Forced Swim test | 16 | Additional file 3: Fig. S3 | NS |
11 | T-maze forced alternation test | 17 | Additional file 3: Fig. S4 | NS |
12 | Barnes maze test | 18 | Additional file 3: Fig. S4 | NS |
13 | Tail suspension test | 32 | Additional file 3: Fig. S3 | Mild ↓depressive-like behavior |
14 | Contextual and cued fear conditioning | 34 | Additional file 3: Fig. S4 | NS |
15 | Social interaction in home cage | 38 | Fig. 6 | ↑ social interaction |