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Fig. 4 | Molecular Brain

Fig. 4

From: Burst firing is required for induction of Hebbian LTP at lateral perforant path to hippocampal granule cell synapses

Fig. 4

T-type Ca2+ channels contributes to the late phase Hebbian LTP by facilitating AP bursts. A Left & Middle, Voltage responses of a BS cell to somatic rheobase current injection before (red, Con) and after bath application of NiCl2 (50 μM, green). Inset of left panel, the boxed trace in an expanded time scale. Right, Mean values for Finit before and after NiCl2 application (n = 9). B Left, Representative EPSP summation in a BS cell evoked by HFSH-2 of LPP in the presence of NiCl2. Right, Finit of AP bursts evoked by HFSH-2 of LPP in BS cells under control and NiCl2 (n = 13) conditions. C EPSP summation evoked by HFSL-2 (left) and the mean area (right) before and after applying NiCl2 (Con, 2.2 ± 0.2 mV s; NiCl2, 2.0 ± 0.2 mV s; n = 10). D Left, Time courses of normalized EPSP in BS cells before and after HFSH-2 with (green) and without (light red) NiCl2. The control time course was reproduced from Fig. 3D for comparison. Right, Magnitude of HFSH-induced LTP in the early (LTP5, open circle) and late (LTP30, closed circle) phases in BS cells (Control, n = 7; NiCl2, n = 7). E Similar as in D, but evoked by a pairing protocol (Control, n = 14, gray; NiCl2, n = 8, green). Shades and error bars, S.E.M. *p < 0.05. **p < 0.01. ***p < 0.001. n.s., not significant (p > 0.05)

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