Skip to main content
Fig. 9 | Molecular Brain

Fig. 9

From: Burst firing is required for induction of Hebbian LTP at lateral perforant path to hippocampal granule cell synapses

Fig. 9

HFSH activates mGluR5 signaling pathways at LPP-GCs, but not at MPP-GCs. A Left, Representative voltage response to a pairing protocol at LPP-GC synapse in the presence of MPEP (dark green, 25 μM). Middle, Time course of normalized EPSP before and after applying a pairing protocol. Right, Magnitudes late phase (LTP30, closed circle) of LTP in the presence of MPEP [6.0 ± 7.7% vs. 52.6 ± 7.7%, MPEP (n = 8) vs. Con (n = 14), **p < 0.01]. B Similar as in A, but in the presence of AM 251 (light blue, 5 μM). Late LTPAP were not affected by AM251 [50.3 ± 9.9% vs. 52.6 ± 7.7%; AM 251 (n = 4) vs. Con (n = 14)]. C Similar as in A, but in the presence of U73122 (orange, 2 μM). Late LTPAP were significantly inhibited [6.7 ± 14.6% vs. 52.6 ± 7.7%, U73122 (n = 5) vs. Con (n = 14), *p < 0.05]. For comparison of LTP at LPP synapses in AC, the time courses and magnitudes of LTP induced by a pairing protocol are reproduced from Fig. 3H (gray). D Similar as in A, but at MPP-GCs. The data for LTP induced by 50 and 100 Hz pairing protocol shown in Fig. 7I were merged and reproduced as control LTP [38.7 ± 18.8% vs. 43.7 ± 8.4%; MPEP (n = 3) vs. Con (n = 14)]. Shades and error bars, S.E.M. *p < 0.05. **p < 0.01. n.s., not significant (p > 0.05)

Back to article page