Skip to main content
Fig. 3 | Molecular Brain

Fig. 3

From: Interneuronal GluK1 kainate receptors control maturation of GABAergic transmission and network synchrony in the hippocampus

Fig. 3

Pharmacological characterization of spontaneous network activity in neonatal Gad-Grik1−/− mice. A Example traces of spontaneous activity in baseline (i) and upon ATPA (ii) or ACET (iii) application, recorded from CA3 pyramidal cells in acute slices from control (left) and Gad-Grik1−/− (right) mice (P4-6). Inserts on top represent network bursts (marked with asterisk) in expanded time scale. B Basal frequency of spontaneous network bursts from acute control (n = 30 (21)) and Gad-Grik1−/− (n = 24 (19)) neonatal slices (P4-6). *p < 0.05, upaired t-test test. C Effect of ATPA (1 µM) and ACET (200 nM) on burst frequency in control and Gad-Grik1−/− groups. ATPA, n = 14(10) and 10(10); ACET n = 13(10) and 7(6) for control and Gad-Grik1−/−, respectively. Frequency is normalized to the baseline (dashed line). ****p < 0.0001; **p < 0.01; *p < 0.05, paired t-test

Back to article page