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Fig. 6 | Molecular Brain

Fig. 6

From: Interneuronal GluK1 kainate receptors control maturation of GABAergic transmission and network synchrony in the hippocampus

Fig. 6

Behavioral phenotype in Gad-Grik1−/− shows reduced activity and altered cognitive flexibility. A EPM test. (i) total distance traveled (ii) time spent in the open arms (iii) entries to the open arms. * p < 0.05; ** p < 0.01; *** p < 0.001; Holm-Šídák posthoc test after 2-way ANOVA. B OF test. (i) total distance traveled (ii) time spent in the central zone (iii) entries to the central zone. * p < 0.05; ** p < 0.01; *** p < 0.001; Holm-Šídák posthoc test after 2-way ANOVA. C Home-cage activity for single-housed male control and Gad-Grik1−/− mice. The activity score is plotted against time of the day, with 1 h bins. *** p < 0.001, 2-way ANOVA. D OF test, with a novel object placed in the center of the field. Example tracks traveled by a control and Gad-Grik1−/− mouse, and pooled data for the time spent in the central zone. * p < 0.05; Holm-Šídák posthoc test after 2-way ANOVA. E Barnes maze test. Latency to the correct hole in the Barnes maze during training (trials 1–8) and after relocation of the escape box (trials 9–12) for male (i) and female (ii) control and Gad-Grik1−/− mice. (iii) Pooled data on the slope of the learning curve between trials 9–12 (* p < 0.05, two-tailed unpaired t-test). F Flexible sequencing task in the IntelliCage. Arrows denote location reversal times. Gad-Grik1−/− female mice show less correct visits and more incorrect visits after the second reversal. ** p < 0.01, 2-way ANOVA. For all the behavioral data, controls, n = 10 and n = 21, Gad-Grik1−/− n = 11 and n = 9, for males and females, respectively. As an exception, control, n = 15, Gad-Grik1−/− n = 9 for the data in panel F

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