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  1. Alzheimer’s disease (AD) pathology occurs in part as the result of excessive production of β-amyloid (Aβ). Metabotropic glutamate receptor 5 (mGluR5) is now considered a receptor for Aβ and consequently contri...

    Authors: Alison Hamilton, Jessica L Esseltine, Rebecca A DeVries, Sean P Cregan and Stephen S G Ferguson
    Citation: Molecular Brain 2014 7:40
  2. The gamma-amino-butyric acid (GABA) system is a critical mediator of fear extinction process. GABA can induce “phasic” or “tonic” inhibition in neurons through synaptic or extrasynaptic GABAA receptors, respectiv...

    Authors: Afshin Paydar, Boyoung Lee, Gireesh Gangadharan, Sukchan Lee, Eun Mi Hwang and Hee-Sup Shin
    Citation: Molecular Brain 2014 7:39
  3. HIV-associated neurocognitive disorder (HAND) is characterized by development of cognitive, behavioral and motor abnormalities, and occurs in approximately 50% of HIV infected individuals. In the United States...

    Authors: Venkata Subba Rao Atluri, Sudheesh Pilakka-Kanthikeel, Thangavel Samikkannu, Vidya Sagar, Kesava Rao Venkata Kurapati, Shailendra K Saxena, Adriana Yndart, Andrea Raymond, Hong Ding, Oscar Hernandez and Madhavan PN Nair
    Citation: Molecular Brain 2014 7:37
  4. Low-voltage-activated (T-type) calcium channels play a crucial role in a number of physiological processes, including neuronal and cardiac pacemaker activity and nociception. Therefore, finding specific modula...

    Authors: Chris Bladen, Jawed Hamid, Ivana A Souza and Gerald W Zamponi
    Citation: Molecular Brain 2014 7:36
  5. Functional heterologous expression of naturally-expressed and apparently functional mammalian α6*-nicotinic acetylcholine receptors (nAChRs; where ‘*’ indicates presence of additional subunits) has been diffic...

    Authors: Bhagirathi Dash and Ming D Li
    Citation: Molecular Brain 2014 7:35
  6. Neuroinflammation plays a key role in the initiation and progression of neurodegeneration in Alzheimer’s disease (AD). Chronic neuroinflammation results in diminished synaptic plasticity and loss of GluN1 N-methy...

    Authors: Jinhua Ma, Bo-Ryoung Choi, ChiHye Chung, Sun Seek Min, Won Kyung Jeon and Jung-Soo Han
    Citation: Molecular Brain 2014 7:33
  7. Chronic stress is generally known to exacerbate the development of numerous neuropsychiatric diseases such as fear and anxiety disorders, which is at least partially due to the disinhibition of amygdala subseq...

    Authors: Zhi-Peng Liu, Chen Song, Min Wang, Ye He, Xiao-Bin Xu, Han-Qing Pan, Wen-Bing Chen, Wei-Jie Peng and Bing-Xing Pan
    Citation: Molecular Brain 2014 7:32
  8. We previously performed systematic association studies of glutamate receptor gene family members with schizophrenia, and found positive associations of polymorphisms in the GRM3 (a gene of metabotropic glutamate ...

    Authors: Ryuta Fujioka, Takenobu Nii, Akiko Iwaki, Atsushi Shibata, Isao Ito, Kiyoyuki Kitaichi, Masatoshi Nomura, Satoko Hattori, Keizo Takao, Tsuyoshi Miyakawa and Yasuyuki Fukumaki
    Citation: Molecular Brain 2014 7:31
  9. Leucine-rich repeat kinase 2 (LRRK2) mutations are the most common cause of dominant and sporadic Parkinson’s disease (PD), a common neurodegenerative disorder. Yeast-two-hybrid screening using human LRRK2 kin...

    Authors: Sharon L Chan, Ling-Ling Chua, Dario C Angeles and Eng-King Tan
    Citation: Molecular Brain 2014 7:29
  10. Inflammatory reaction in blood–spinal cord barrier (BSCB) plays a crucial role in ischemia/reperfusion (I/R) injury. It has been shown that microglia could be activated through Toll-like receptors (TLRs). Ther...

    Authors: Xiao-Qian Li, Jun Wang, Bo Fang, Wen-Fei Tan and Hong Ma
    Citation: Molecular Brain 2014 7:28
  11. Itch, chronic itch in particular, can have a significant negative impact on an individual’s quality of life. However, the molecular mechanisms underlying itch processing in the central nervous system remain la...

    Authors: Ling Zhang, Guan-Yu Jiang, Ning-Jing Song, Ying Huang, Jia-Yin Chen, Qing-Xiu Wang and Yu-Qiang Ding
    Citation: Molecular Brain 2014 7:25
  12. The common marmoset (Callithrix jacchus) is a New World primate sharing many similarities with humans. Recently developed technology for generating transgenic marmosets has opened new avenues for faithful recapit...

    Authors: Zhi Zhou, Kazuhisa Kohda, Keiji Ibata, Jun Kohyama, Wado Akamatsu, Michisuke Yuzaki, Hirotaka James Okano, Erika Sasaki and Hideyuki Okano
    Citation: Molecular Brain 2014 7:24
  13. Loss of adenomatous polyposis coli (APC) gene function results in constitutive activation of the canonical Wnt pathway and represents the main initiating and rate-limiting event in colorectal tumorigenesis. APC i...

    Authors: Takanori Onouchi, Katsunori Kobayashi, Kazuyoshi Sakai, Atsushi Shimomura, Ron Smits, Chiho Sumi-Ichinose, Masafumi Kurosumi, Keizo Takao, Ryuji Nomura, Akiko Iizuka-Kogo, Hidenori Suzuki, Kazunao Kondo, Tetsu Akiyama, Tsuyoshi Miyakawa, Riccardo Fodde and Takao Senda
    Citation: Molecular Brain 2014 7:21
  14. Higher brain function is supported by the precise temporal and spatial regulation of thousands of genes. The mechanisms that underlie transcriptional regulation in the brain, however, remain unclear. The Ntng1 an...

    Authors: Kunio Yaguchi, Sachiko Nishimura-Akiyoshi, Satoshi Kuroki, Takashi Onodera and Shigeyoshi Itohara
    Citation: Molecular Brain 2014 7:19
  15. Adeno-associated virus (AAV) vectors can deliver transgenes to diverse cell types and are therefore useful for basic research and gene therapy. Although AAV has many advantages over other viral vectors, its re...

    Authors: Jun-Hyeok Choi, Nam-Kyung Yu, Gi-Chul Baek, Joseph Bakes, Daekwan Seo, Hye Jin Nam, Sung Hee Baek, Chae-Seok Lim, Yong-Seok Lee and Bong-Kiun Kaang
    Citation: Molecular Brain 2014 7:17
  16. Rats exhibit extremely limited motor function recovery after total transection of the spinal cord (SCT). We previously reported that SM-216289, a semaphorin3A inhibitor, enhanced axon regeneration and motor fu...

    Authors: Liang Zhang, Shinjiro Kaneko, Kaoru Kikuchi, Akihiko Sano, Miho Maeda, Akiyoshi Kishino, Shinsuke Shibata, Masahiko Mukaino, Yoshiaki Toyama, Meigen Liu, Toru Kimura, Hideyuki Okano and Masaya Nakamura
    Citation: Molecular Brain 2014 7:14
  17. Excess expression of acetylcholinesterase (AChE) in the cortex and hippocampus causes a decrease in the number of glutamatergic synapses and alters the expression of neurexin and neuroligin, trans-synaptic pro...

    Authors: Yun-Yan Xiang, Haiheng Dong, Burton B Yang, John F MacDonald and Wei-Yang Lu
    Citation: Molecular Brain 2014 7:15
  18. We have previously identified BRINP (BMP/RA-inducible neural-specific protein-1, 2, 3) family genes that possess the ability to suppress cell cycle progression in neural stem cells. Of the three family members...

    Authors: Miwako Kobayashi, Toshiyuki Nakatani, Toshiaki Koda, Ken-ichi Matsumoto, Ryosuke Ozaki, Natsuki Mochida, Keizo Takao, Tsuyoshi Miyakawa and Ichiro Matsuoka
    Citation: Molecular Brain 2014 7:12
  19. Repetitive Transcranial Magnetic Stimulation (rTMS)/ Deep-brain Magnetic Stimulation (DMS) is an effective therapy for various neuropsychiatric disorders including major depression disorder. The molecular and ...

    Authors: Yan Zhang, Rong-Rong Mao, Zhi-Fang Chen, Meng Tian, Da-Li Tong, Zheng-Run Gao, Min Huang, Xiao Li, Xiu Xu, Wen-Hao Zhou, Cheng-Yu Li, Jiang Wang, Lin Xu and Zilong Qiu
    Citation: Molecular Brain 2014 7:11
  20. VPS35 (vacuolar protein sorting 35) is a major component of retromer that selectively promotes endosome-to-Golgi retrieval of transmembrane proteins. Dysfunction of retromer is a risk factor for the pathogenes...

    Authors: Wei Liu, Fu-Lei Tang, Joanna Erion, Hang Xiao, Jian Ye and Wen-Cheng Xiong
    Citation: Molecular Brain 2014 7:10
  21. Group I metabotropic glutamate receptors (mGlu1/5 receptors) have important roles in synaptic activity in the central nervous system. They modulate neuronal excitability by mobilizing intracellular Ca2+ following...

    Authors: Seung-Eon Roh, Yun Hwa Hong, Dong Cheol Jang, Jun Kim and Sang Jeong Kim
    Citation: Molecular Brain 2014 7:9
  22. The voltage-gated potassium channel Kv1.4 is an important A-type potassium channel and modulates the excitability of neurons in central nervous system. Analysis of the interaction between Kv1.4 and its interac...

    Authors: Chunliang Xie, Haibo Su, Tianyao Guo, Yizhong Yan, Xiaozhen Peng, Rui Cao, Ying Wang, Ping Chen, Xianchun Wang and Songping Liang
    Citation: Molecular Brain 2014 7:4
  23. The output of the neuronal digital spikes is fulfilled by axonal propagation and synaptic transmission to influence postsynaptic cells. Similar to synaptic transmission, spike propagation on the axon is not se...

    Authors: Zhilai Yang, Erwei Gu, Xianfu Lu and Jin-Hui Wang
    Citation: Molecular Brain 2014 7:1
  24. Neuropeptides are a diverse category of signaling molecules in the nervous system regulating a variety of processes including food intake, social behavior, circadian rhythms, learning, and memory. Both the ide...

    Authors: Joseph P Salisbury, Kristin J Boggio, Yun-Wei A Hsu, Jeniffer Quijada, Anna Sivachenko, Gabriele Gloeckner, Paul J Kowalski, Michael L Easterling, Michael Rosbash and Jeffrey N Agar
    Citation: Molecular Brain 2013 6:60
  25. Several etiological reports have shown that chronic pain significantly interferes with sleep. Inadequate sleep due to chronic pain may contribute to the stressful negative consequences of living with pain. How...

    Authors: Hisakatsu Ito, Makoto Yanase, Akira Yamashita, Chigusa Kitabatake, Asami Hamada, Yuki Suhara, Michiko Narita, Daigo Ikegami, Hiroyasu Sakai, Mitsuaki Yamazaki and Minoru Narita
    Citation: Molecular Brain 2013 6:59
  26. The α7 nicotinic acetylcholine receptor (nAchR) and NMDA glutamate receptor (NMDAR) are both ligand-gated ion channels permeable to Ca2+ and Na+. Previous studies have demonstrated functional modulation of NMDARs...

    Authors: Shupeng Li, Qiang Nai, Tatiana V Lipina, John C Roder and Fang Liu
    Citation: Molecular Brain 2013 6:58
  27. Noncompetitive N-methyl-d-aspartate (NMDA) receptor antagonists evoke a behavioral and neurobiological syndrome in experimental animals. We previously reported that phencyclidine (PCP), an NMDA receptor antagonis...

    Authors: Hideko Yamamoto, Etsuko Kamegaya, Wakako Sawada, Ryota Hasegawa, Toshifumi Yamamoto, Yoko Hagino, Yukio Takamatsu, Kazuhide Imai, Hisashi Koga, Masayoshi Mishina and Kazutaka Ikeda
    Citation: Molecular Brain 2013 6:56
  28. Huntington Disease (HD) is a neurodegenerative disorder resulting from the expansion of polyglutamine stretch in the huntingtin protein (Htt). Mutant HTT (mHtt) leads to progressive impairment of several molec...

    Authors: Alba Di Pardo, Silvia Alberti, Vittorio Maglione, Enrico Amico, Etty P Cortes, Francesca Elifani, Giuseppe Battaglia, Carla L Busceti, Ferdinando Nicoletti, JeanPaul G Vonsattel and Ferdinando Squitieri
    Citation: Molecular Brain 2013 6:55
  29. Glutamate is the major neurotransmitter that mediates a principal form of excitatory synaptic transmission in the brain. From the presynaptic terminals of neurons, glutamate is released upon exocytosis of the ...

    Authors: Hyungju Park, Kyung-Seok Han, Soo-Jin Oh, Seonmi Jo, Junsung Woo, Bo-Eun Yoon and C Justin Lee
    Citation: Molecular Brain 2013 6:54
  30. Sensory input is generally thought to be necessary for refining and consolidating neuronal connections during brain development. We here report that cortical callosal axons in somatosensory cortex require sens...

    Authors: Ying Huang, Ning-Ning Song, Wei Lan, Qiong Zhang, Ling Zhang, Lei Zhang, Ling Hu, Jia-Yin Chen, Chun-Jie Zhao, Lingjiang Li, Lin Xu and Yu-Qiang Ding
    Citation: Molecular Brain 2013 6:53
  31. Congenital disorders of glycosylation (CDGs) are inherited diseases caused by glycosylation defects. Incorrectly glycosylated proteins induce protein misfolding and endoplasmic reticulum (ER) stress. The most ...

    Authors: Liangwu Sun, Yingjun Zhao, Kun Zhou, Hudson H Freeze, Yun-wu Zhang and Huaxi Xu
    Citation: Molecular Brain 2013 6:52

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