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Archived Comments for: Alpha-CaMKII deficiency causes immature dentate gyrus, a novel candidate endophenotype of psychiatric disorders

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  1. Additional Information

    Tsuyoshi Miyakawa, Fujita Health University

    6 January 2012

    1. This paper was translated into Belorussian language, thanks to the effort of Nadejda Dobkina.
    http://onlinepharmacycheck.com/~doc/molecularbrain-content-be

    2. Now, we are showing how to take out whole dentate gyrus from mice in a video journal, Journal of Visualized Experiments (JoVE). The gene expression differences in the DG of alpha-CaMKII HKO mice are much more clearer (See the text in the JoVE article).
    http://www.jove.com/details.php?id=1543

    3. We have demonstrated that chronic fluoxetine (a SSRI; Prozac) treatment causes "dematuration" of almost all DG granule cells, causing dramatic changes of electrophysiological properties of DG neurons and resulting in a phenotype we call "immature dentate gyrus (iDG)" (Kobayashi et al., PNAS, 2010). Transcriptome pattern in the hipocampus of SSRI-treated wild type mice is strikingly similar to the ones seen in the alpha-CaMKII HKO mice. In fact, iDG-like phenomena can be seen a few other genetically-engineered mice and other drug-treated mice (our unpublished observation).

    Competing interests

    None declared

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