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Archived Comments for: Alpha-CaMKII deficiency causes immature dentate gyrus, a novel candidate endophenotype of psychiatric disorders

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  1. Additional Information

    Tsuyoshi Miyakawa, Fujita Health University

    6 January 2012

    1. This paper was translated into Belorussian language, thanks to the effort of Nadejda Dobkina.

    2. Now, we are showing how to take out whole dentate gyrus from mice in a video journal, Journal of Visualized Experiments (JoVE). The gene expression differences in the DG of alpha-CaMKII HKO mice are much more clearer (See the text in the JoVE article).

    3. We have demonstrated that chronic fluoxetine (a SSRI; Prozac) treatment causes "dematuration" of almost all DG granule cells, causing dramatic changes of electrophysiological properties of DG neurons and resulting in a phenotype we call "immature dentate gyrus (iDG)" (Kobayashi et al., PNAS, 2010). Transcriptome pattern in the hipocampus of SSRI-treated wild type mice is strikingly similar to the ones seen in the alpha-CaMKII HKO mice. In fact, iDG-like phenomena can be seen a few other genetically-engineered mice and other drug-treated mice (our unpublished observation).

    Competing interests

    None declared