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Research
We have recently shown that pharmacological blockade of mGlu2 metabotropic glutamate receptors protects vulnerable neurons in the 4-vessel occlusion model of transient global ischemia, whereas receptor activat...
Molecular Brain 2017 10:39
Published on: 18 August 2017
Research
Lewy body dementias are the second most common cause of neurodegenerative dementia in the elderly after Alzheimer’s disease (AD). The two clinical subgroups of Lewy body dementias, namely, dementia with Lewy b...
Molecular Brain 2017 10:36
Published on: 11 August 2017
Research
The G protein-coupled receptor 55 (GPR55) is a novel cannabinoid receptor, whose exact role in anxiety remains unknown. The present study was conducted to explore the possible mechanisms by which GPR55 regulat...
Molecular Brain 2017 10:38
Published on: 11 August 2017
Research
Calmodulin (CaM) is an important signaling molecule that regulates a vast array of cellular functions by activating second messengers involved in cell function and plasticity. Low voltage-activated calcium cha...
Molecular Brain 2017 10:37
Published on: 11 August 2017
Review
Alzheimer’s disease (AD) is defined by the excessive accumulation of toxic peptides, such as beta amyloid (Aβ) plaques and intracellular neurofibrillary tangles (NFT). The risk factors associated with AD inclu...
Molecular Brain 2017 10:35
Published on: 1 August 2017
Research
Spinocerebellar ataxia (SCA) is an autosomal dominant neurodegenerative disorder characterized by slowly progressive cerebellar dysfunction. Currently, 42 SCA types are known, some of which are caused by CAG r...
Molecular Brain 2017 10:34
Published on: 24 July 2017
Review
For centuries analyses of tissues have depended on sectioning methods. Recent developments of tissue clearing techniques have now opened a segway from studying tissues in 2 dimensions to 3 dimensions. This par...
Molecular Brain 2017 10:33
Published on: 20 July 2017
Research
Post-translational modification on protein Ser/Thr residues by O-linked attachment of ß-N-acetyl-glucosamine (O-GlcNAcylation) is a key mechanism integrating redox signaling, metabolism and stress responses. O...
Molecular Brain 2017 10:32
Published on: 19 July 2017
Research
A hallmark of temporal lobe epilepsy (TLE) is hippocampal neuronal demise and aberrant mossy fiber sprouting. In addition, unrestrained neuronal activity in TLE patients induces gene expression including immed...
Molecular Brain 2017 10:30
Published on: 17 July 2017
Research
Reliable and reproducible assessment of animal learning and behavior is a central aim of basic and translational neuroscience research. Recent developments in automated operant chamber technology have led to t...
Molecular Brain 2017 10:31
Published on: 17 July 2017
Research
Mechano growth factor (MGF) is a splice variant of IGF-1 first described in skeletal muscle. MGF induces muscle cell proliferation in response to muscle stress and injury. In control mice we found endogenous e...
Molecular Brain 2017 10:23
Published on: 7 July 2017
Short report
Studies have implied that the circadian oscillation of mitogen-activated protein kinase (MAPK) signal pathways is crucial for hippocampus-dependent memory. NF1 mouse models (Nf1 heterozygous null mutants; Nf1 ...
Molecular Brain 2017 10:29
Published on: 3 July 2017
Short report
Toll-like receptor 2 (TLR2) was recently shown to contribute to secondary brain damage after intracerebral hemorrhage (ICH), although the molecular mechanisms of this contribution are elusive. In this study, w...
Molecular Brain 2017 10:27
Published on: 24 June 2017
Review
Depression is a polygenic and highly complex psychiatric disorder that remains a major burden on society. Antidepressants, such as selective serotonin reuptake inhibitors (SSRIs), are some of the most commonly...
Molecular Brain 2017 10:28
Published on: 24 June 2017
Review
Mounting evidence suggests that the nervous and immune systems are intricately linked. Many proteins first identified in the immune system have since been detected at synapses, playing different roles in norma...
Molecular Brain 2017 10:26
Published on: 20 June 2017
Review
Microglia are the principal resident immune cells in the central nervous system and are believed to be versatile players in both inflammatory and physiological contexts. On the one hand, in order to safeguard ...
Molecular Brain 2017 10:25
Published on: 19 June 2017
Research
The effects of general anesthetics on inducing neuronal apoptosis during early brain development are well-documented. However, since physiological apoptosis also occurs during this developmental window, it is ...
Molecular Brain 2017 10:24
Published on: 17 June 2017
Research
Amyotrophic lateral sclerosis, a devastating neurodegenerative disease, is characterized by the progressive loss of motor neurons and the accumulation of misfolded protein aggregates. The latter suggests impai...
Molecular Brain 2017 10:22
Published on: 13 June 2017
Research
Excitatory synaptic transmission in central synapses is modulated by serotonin (5-HT). The anterior cingulate cortex (ACC) is an important cortical region for pain perception and emotion. ACC neurons receive i...
Molecular Brain 2017 10:21
Published on: 12 June 2017
Research
Although post-ischemic inflammation induced by the innate immune response is considered an essential step in the progression of cerebral ischemia injury, the role of triggering receptor expressed on myeloid ce...
Molecular Brain 2017 10:20
Published on: 7 June 2017
Research
Apolipoprotein E4 (ApoE4) is a major genetic risk factor for sporadic or late onset Alzheimer’s disease (AD). Brain-derived neurotrophic factor (BDNF) is decreased by 3 to 4-fold in the brains of AD patients a...
Molecular Brain 2017 10:19
Published on: 1 June 2017
Review
Since 2009, evidence has accumulated to suggest that Tau aggregates form first in a small number of brain cells, from where they propagate to other regions, resulting in neurodegeneration and disease. Propagat...
Molecular Brain 2017 10:18
Published on: 30 May 2017
Research
Proper recognition between axons and glial processes is required for the establishment of axon ensheathment in the developing nervous system. Recent studies have begun to reveal molecular events underlying dev...
Molecular Brain 2017 10:17
Published on: 23 May 2017
Review
The study of glutamatergic synapses mainly focuses on the memory-related hippocampus. Recent studies in the cortical areas such as the anterior cingulate cortex (ACC) show that excitatory synapses can undergo ...
Molecular Brain 2017 10:16
Published on: 18 May 2017
Review
Support for the N-methyl-d-aspartate receptor (NMDAR) hypofunction hypothesis of schizophrenia has led to increasing focus on restoring proper glutamatergic signaling as an approach for treatment of this devastat...
Molecular Brain 2017 10:15
Published on: 26 April 2017
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