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  1. T-type calcium channelopathies encompass a group of human disorders either caused or exacerbated by mutations in the genes encoding different T-type calcium channels. Recently, a new heterozygous missense muta...

    Authors: Robin N. Stringer, Leos Cmarko, Gerald W. Zamponi, Michel De Waard and Norbert Weiss
    Citation: Molecular Brain 2023 16:68
    Content type: Micro report Published on:

  2. Huntington’s Disease (HD) is an inherited autosomal dominant neurodegenerative disorder that leads to progressive motor and cognitive impairment due to the expansion of a polyglutamine (CAG) repeat in the N-te...

    Authors: Si Han Li, Tash-Lynn L. Colson, Jingwei Chen, Khaled S. Abd-Elrahman and Stephen S. G. Ferguson
    Citation: Molecular Brain 2023 16:67
    Content type: Research Published on:

  3. Viral transsynaptic labeling has become indispensable for investigating the functional connectivity of neural circuits in the mammalian brain. Adeno-associated virus serotype 1 (AAV1) allows for anterograde tr...

    Authors: Islam Faress, Valentina Khalil, Haruka Yamamoto, Szilard Sajgo, Keisuke Yonehara and Sadegh Nabavi
    Citation: Molecular Brain 2023 16:66
    Content type: Micro report Published on:

  4. Parkinson’s disease (PD) is characterized by a selective loss of dopaminergic neurons. While most research on PD conducted to date has focused on neurons and, to a certain extent, glia, few studies have invest...

    Authors: Eun-Jin Bae, Dayana Pérez-Acuña, Ka Hyun Rhee and Seung-Jae Lee
    Citation: Molecular Brain 2023 16:65
    Content type: Micro report Published on:

  5. The insula and anterior cingulate cortex (ACC) are brain regions that undergo structural and functional reorganization in neuropathic pain states. Here, we aimed to study inhibitory parvalbumin positive (PV+) ...

    Authors: Heloísa Alonso-Matielo, Zizhen Zhang, Eder Gambeta, Junting Huang, Lina Chen, Gabriel Oliveira de Melo, Camila Squarzoni Dale and Gerald W. Zamponi
    Citation: Molecular Brain 2023 16:64
    Content type: Micro report Published on:

  6. Alzheimer’s disease (AD) is a neurodegenerative disease characterized by Aβ deposition, tauopathy, neuroinflammation, and impaired cognition. The recent identification of associations between protein kinases a...

    Authors: Hyun-ju Lee, Jeong-Woo Hwang, Jin-Hee Park, Yoo Joo Jeong, Ji-Yeong Jang and Hyang-Sook Hoe
    Citation: Molecular Brain 2023 16:63
    Content type: Micro report Published on:

  7. Amyotrophic lateral sclerosis (ALS) is a disease that affects motor neurons and has a poor prognosis. We focused on TAR DNA-binding protein 43 kDa (TDP-43), which is a common component of neuronal inclusions i...

    Authors: Asako Onda-Ohto, Minami Hasegawa-Ogawa, Hiromasa Matsuno, Tomotaka Shiraishi, Keiko Bono, Hiromi Hiraki, Yumi Kanegae, Yasuyuki Iguchi and Hirotaka James Okano
    Citation: Molecular Brain 2023 16:62
    Content type: Research Published on:

  8. Changes in neural activity induced by learning and novel environments have been reported to lead to the formation of new synapses in the adult brain. However, the underlying molecular mechanism is not well und...

    Authors: Takahiro Aimi, Keiko Matsuda and Michisuke Yuzaki
    Citation: Molecular Brain 2023 16:61
    Content type: Research Published on:

  9. The present study was undertaken to explore the relative contributions of Cav3.2 T-type channels to mediating the antihyperalgesic activity of joint manipulation (JM) therapy. We used the chronic constriction ...

    Authors: Daniel F. Martins, Victor Sorrentino, Leidiane Mazzardo-Martins, William R. Reed, Adair R. S. Santos, Vinícius M. Gadotti and Gerald W. Zamponi
    Citation: Molecular Brain 2023 16:60
    Content type: Micro report Published on:

  10. Schizophrenia is a psychiatric disorder that affects around 1% of the population in widespread populations, with severe cases leading to long-term hospitalization and necessitation of lifelong treatment. Recen...

    Authors: Siyao Li, Koki Sakurai, Masahiro Ohgidani, Takahiro A. Kato and Takatoshi Hikida
    Citation: Molecular Brain 2023 16:59
    Content type: Research Published on:

  11. Intrinsic plasticity of the cerebellar Purkinje cell (PC) plays a critical role in motor memory consolidation. However, detailed changes in their intrinsic properties during memory consolidation are not well u...

    Authors: Dong Cheol Jang, Geehoon Chung, Sun Kwang Kim and Sang Jeong Kim
    Citation: Molecular Brain 2023 16:58
    Content type: Research Published on:

  12. The 18 kDa translocator protein (TSPO) is a classical marker of neuroinflammation targeted for in vivo molecular imaging. Microglial cells were originally thought to be the only source of TSPO overexpression b...

    Authors: Kelly Ceyzériat, Alekos Nicolaides, Quentin Amossé, Christine Fossey, Thomas Cailly, Frédéric Fabis, Valentina Garibotto, Carole Escartin, Benjamin B. Tournier and Philippe Millet
    Citation: Molecular Brain 2023 16:57
    Content type: Research Published on:

  13. RET (REarranged during Transfection) is a receptor tyrosine kinase that transduces various external stimuli into biological functions, such as survival and differentiation, in neurons. In the current study, we...

    Authors: Bobae Hyeon, Heeyoung Lee, Nury Kim and Won Do Heo
    Citation: Molecular Brain 2023 16:56
    Content type: Research Published on:

  14. Plasticity of principal cells and inhibitory interneurons underlies hippocampal memory. Bidirectional modulation of somatostatin cell mTORC1 activity, a crucial translational control mechanism in synaptic plas...

    Authors: François-Xavier Michon, Isabel Laplante, Anthony Bosson, Richard Robitaille and Jean-Claude Lacaille
    Citation: Molecular Brain 2023 16:55
    Content type: Research Published on:

  15. Itch is a complex aversive sensory and emotional experience. As a most upsetting symptom in many dermatological and systemic diseases, it lacks efficient treatments. The lateral habenula nucleus (LHb) encodes ...

    Authors: Rui Chen, Xiang Xu, Xin-Yue Wang, Wen-Bin Jia, De-Shan Zhao, Na Liu, Zhen Pang, Xiao-Qing Liu and Yan Zhang
    Citation: Molecular Brain 2023 16:54
    Content type: Research Published on:

  16. The regulation of neural stem cell (NSC) proliferation and differentiation during brain development is a precisely controlled process, with the production of different neuronal subtypes governed by strict time...

    Authors: Shukui Zhang, Jinyue Zhao, Cheng Zhao, Libo Su and Jianwei Jiao
    Citation: Molecular Brain 2023 16:53
    Content type: Research Published on:

  17. Angiotensin (Ang)-converting-enzyme (ACE) 2 converts Ang II into Ang (1–7), which in turn acts on MAS receptors (ACE2/Ang (1–7)/MAS receptors pathway). This pathway has neuroprotective properties, making it a ...

    Authors: Osamu Nakagawasai, Kohei Takahashi, Taisei Koyama, Ryota Yamagata, Wataru Nemoto and Koichi Tan-No
    Citation: Molecular Brain 2023 16:52
    Content type: Research Published on:

  18. Itch is a distinctive sensation that causes a specific affection and scratching reaction. The anterior cingulate cortex (ACC) has been linked to itch sensation in numerous studies; however, its precise functio...

    Authors: Chiwoo Lee, Jihae Oh, Jae-Hyung Lee, Bong-Kiun Kaang and Hyoung-Gon Ko
    Citation: Molecular Brain 2023 16:51
    Content type: Micro report Published on:

  19. Mice hippocampus contains three prominent subregions, CA1, CA3 and DG and is well regarded as an essential multiple task processor for learning, memory and cognition based on tremendous studies on these three ...

    Authors: Siqi Peng, Wenzhen Gu, Wenxiu Zhu, Yan Zhuang, Xiuqi Yang, Yaochen Lv, Sibie Meng, Wei Xie and Moyi Li
    Citation: Molecular Brain 2023 16:50
    Content type: Methodology Published on:

  20. The relationship between autism spectrum disorder (ASD) and dendritic spine abnormalities is well known, but it is unclear whether the deficits relate to specific neuron types and brain regions most relevant t...

    Authors: Lucia Celora, Fanny Jaudon, Carmela Vitale and Lorenzo A. Cingolani
    Citation: Molecular Brain 2023 16:49
    Content type: Micro report Published on:

  22. Delta-9-tetrahydrocannabinol (Δ9-THC) is known to produce systemic analgesia that involves CB1 and CB2 cannabinoid receptors. However, there is compelling evidence that Δ9-THC can potently inhibit Cav3.2T-type ca...

    Authors: Vinicius de Maria Gadotti, Flavia Tasmin Techera Antunes and Gerald W. Zamponi
    Citation: Molecular Brain 2023 16:47
    Content type: Micro report Published on:

  23. Social behavior emerges early in development, a time marked by the onset of neurodevelopmental disorders featuring social deficits, including autism spectrum disorder (ASD). Although social deficits are at the...

    Authors: Melina Matthiesen, Abdessattar Khlaifia, Carl Frank David Steininger Jr, Maryam Dadabhoy, Unza Mumtaz and Maithe Arruda-Carvalho
    Citation: Molecular Brain 2023 16:46
    Content type: Research Published on:

  24. High frequency burst firing is critical in summation of back-propagating action potentials (APs) in dendrites, which may greatly depolarize dendritic membrane potential. The physiological significance of burst...

    Authors: Yoonsub Kim, Sooyun Kim, Won-Kyung Ho and Suk-Ho Lee
    Citation: Molecular Brain 2023 16:45
    Content type: Research Published on:

  25. Glycine receptors (GlyRs) are ligand-gated chloride channels comprising alpha (α1–4) and β subunits. The GlyR subunits play major roles in the mammalian central nervous system, ranging from regulating simple s...

    Authors: Mohamed Darwish, Satoko Hattori, Hirofumi Nishizono, Tsuyoshi Miyakawa, Nozomu Yachie and Keizo Takao
    Citation: Molecular Brain 2023 16:44
    Content type: Research Published on:

  26. Kainate type glutamate receptors (KARs) are strongly expressed in GABAergic interneurons and have the capability of modulating their functions via ionotropic and G-protein coupled mechanisms. GABAergic interne...

    Authors: Simo Ojanen, Tatiana Kuznetsova, Zoia Kharybina, Vootele Voikar, Sari E. Lauri and Tomi Taira
    Citation: Molecular Brain 2023 16:43
    Content type: Research Published on:

  27. Dysregulation of HDAC4 expression and/or nucleocytoplasmic shuttling results in impaired neuronal morphogenesis and long-term memory in Drosophila melanogaster. A recent genetic screen for genes that interact in ...

    Authors: Silvia Schwartz, Sarah J Wilson, Tracy K Hale and Helen L Fitzsimons
    Citation: Molecular Brain 2023 16:42
    Content type: Short report Published on:

  28. The primary cilium, an antenna-like structure on the cell surface, acts as a mechanical and chemical sensory organelle. Primary cilia play critical roles in sensing the extracellular environment to coordinate ...

    Authors: Ji-Eun Bae, Soyoung Jang, Joon Bum Kim, Hyejin Hyung, Na Yeon Park, Yong Hwan Kim, So Hyun Kim, Seong Hyun Kim, Jin Min Ha, Gyeong Seok Oh, Kyuhee Park, Kwiwan Jeong, Jae Seon Jang, Doo Sin Jo, Pansoo Kim, Hyun-Shik Lee…
    Citation: Molecular Brain 2023 16:41
    Content type: Research Published on:

  29. Cooperation is a social behavior crucial for the survival of many species, including humans. Several experimental paradigms have been established to study cooperative behavior and related neural activity in di...

    Authors: Ke-Ming Zhang, Yan Shen, Chun-Hui Jia, Hao Wang, Guo-Qiang Bi and Pak-Ming Lau
    Citation: Molecular Brain 2023 16:40
    Content type: Micro report Published on:

  30. Stroke is a common cerebrovascular disease with great danger to public health. Educational inequality is a universal issue that influences populations’ stroke risk. This study aimed to investigate the causal r...

    Authors: Bangbei Wan, Ning Ma, Zhi Zhou and Weiying Lu
    Citation: Molecular Brain 2023 16:39
    Content type: Research Published on:

  31. Characterization of inter-regional interactions in brain is essential for understanding the mechanism relevant to normal brain function and neurological disease. The recently developed flexible micro (μ)-elect...

    Authors: Susumu Setogawa, Ryota Kanda, Shuto Tada, Takuya Hikima, Yoshito Saitoh, Mikiko Ishikawa, Satoshi Nakada, Fumiko Seki, Keigo Hikishima, Hideyuki Matsumoto, Kenji Mizuseki, Osamu Fukayama, Makoto Osanai, Hiroto Sekiguchi and Noriaki Ohkawa
    Citation: Molecular Brain 2023 16:38
    Content type: Methodology Published on:

  32. Profiling molecular expression in situ allows the integration of biomolecular and cellular features, enabling an in-depth understanding of biological systems. Multiplexed immunofluorescence methods can visuali...

    Authors: Wonjin Cho, Sehun Kim and Young-Gyun Park
    Citation: Molecular Brain 2023 16:37
    Content type: Nano review Published on:

  33. Increasing evidence indicates the major role of mitochondrial function in neurodegenerative disease. However, it is unclear whether mitochondrial dynamics directly affect postoperative neurocognitive disorder ...

    Authors: Zhibin Xiao, Xiajing Zhang, Guangyao Li, Li Sun, Jiangjing Li, Ziwei Jing, Qingya Qiu, Guangxiang He, Changjun Gao and Xude Sun
    Citation: Molecular Brain 2023 16:36
    Content type: Research Published on:

  35. Microglia, as macrophages in the brain, are responsible for immune responses and synaptic remodeling. Although the function of microglia is regulated by circadian rhythms, it is still unclear whether microglia...

    Authors: Futaba Matsui, Sho T. Yamaguchi, Riho Kobayashi, Shiho Ito, Sakimi Nagashima, Zhiwen Zhou and Hiroaki Norimoto
    Citation: Molecular Brain 2023 16:34
    Content type: Micro report Published on:

  36. FMRP, an RNA-binding protein, has previously shown to be involved in regulation of circadian rhythms in flies and mice. However, the molecular mechanism remains elusive. Here we demonstrate that core circadian...

    Authors: Xiangrong Tang, Jing Zhang, Xin Li, Ying Hu, Dengfeng Liu, Jia-Da Li and Renbin Lu
    Citation: Molecular Brain 2023 16:33
    Content type: Research Published on:

  37. The serotonin transporter (5-HTT) plays a critical role in the regulation of serotonin neurotransmission. Mice genetically deficient in 5-HTT expression have been used to study the physiological functions of 5...

    Authors: Hirotaka Shoji, Kazutaka Ikeda and Tsuyoshi Miyakawa
    Citation: Molecular Brain 2023 16:32
    Content type: Research Published on:

  38. Cognitive functions depend on the time of day in various organisms. Previously, we found that 24-h recognition memory performance of nocturnal mice changes diurnally through SCOP protein-dependent regulation. ...

    Authors: Kimiko Shimizu, Ken-ichi Inoue, Takao Oishi, Masahiko Takada, Yoshitaka Fukada and Hiroo Imai
    Citation: Molecular Brain 2023 16:31
    Content type: Research Published on:

  39. Neuronal voltage changes which are dependent on chloride transporters and channels are involved in forming neural functions during early development and maintaining their stability until adulthood. The intrace...

    Authors: Yanruo Huang, Qihang Wang, Yunsong Peng, Wenjie Du, Qi Wang, Jiangtao Qi, Zijian Hao and Yingwei Wang
    Citation: Molecular Brain 2023 16:30
    Content type: Research Published on:

  41. Taste plays an essential role in the evaluation of food quality by detecting potential harm and benefit in what animals are about to eat and drink. While the affective valence of taste signals is supposed to b...

    Authors: Shun Hamada, Kaori Mikami, Shuhei Ueda, Masashi Nagase, Takashi Nagashima, Mikiyasu Yamamoto, Haruhiko Bito, Sayaka Takemoto-Kimura, Toshihisa Ohtsuka and Ayako M. Watabe
    Citation: Molecular Brain 2023 16:28
    Content type: Research Published on:

  42. Nav1.8-positive afferent fibers are mostly nociceptors playing a role in mediating thermal and mechanical pain, but mechanoreceptors within these afferents have not been fully investigated. In this study, we g...

    Authors: Akihiro Yamada, Ayaka I. Yamada, Jennifer Ling, Hidemasa Furue, Wenqin Luo and Jianguo G. Gu
    Citation: Molecular Brain 2023 16:27
    Content type: Research Published on:

  43. Metabolites secreted by the gut microbiota may play an essential role in microbiota–gut–central nervous system crosstalk. In this study, we explored the changes occurring in the gut microbiota and their metabo...

    Authors: Ganggang Kong, Wenwu Zhang, Siyun Zhang, Jiewen Chen, kejun He, Changming Zhang, Xi Yuan and Baoshu Xie
    Citation: Molecular Brain 2023 16:26
    Content type: Research Published on:

  44. The islet amyloid polypeptide (IAPP), a pancreas-produced peptide, has beneficial functions in its monomeric form. However, IAPP aggregates, related to type 2 diabetes mellitus (T2DM), are toxic not only for t...

    Authors: Cristina Nuñez-Diaz, Dovilė Pocevičiūtė, Nina Schultz, Charlotte Welinder, Karl Swärd and Malin Wennström
    Citation: Molecular Brain 2023 16:25
    Content type: Research Published on:

  45. The prenylation of proteins is involved in a variety of biological functions. However, it remains unknown whether it plays an important role in the morphogenesis of the cerebellum. To address this question, we...

    Authors: Qi Cheng, Jing Wu, Yingqian Xia, Qing Cheng, Yinjuan Zhao, Peixiang Zhu, Wangling Zhang, Shihu Zhang, Lei Zhang, Yushan Yuan, Chaojun Li, Guiquan Chen and Bin Xue
    Citation: Molecular Brain 2023 16:24
    Content type: Research Published on:

  46. Jacob is a synapto-nuclear messenger protein that encodes and transduces the origin of synaptic and extrasynaptic NMDA receptor signals to the nucleus. The protein assembles a signalosome that differs in case ...

    Authors: Guilherme M. Gomes, Julia Bär, Anna Karpova and Michael R. Kreutz
    Citation: Molecular Brain 2023 16:23
    Content type: Micro report Published on:

  47. Melanoma-associated antigen D1 (Maged1) has critical functions in the central nervous system in both developmental and adult stages. Loss of Maged1 in mice has been linked to depression, cognitive disorder, an...

    Authors: Jie Wang, Sheng-Ye Xu, Zhi-Yuan Ye, Zhou-Na Sun, Jia-Qi Zhang, Cui Qi, Rui Liu, Xiang Gao, Chuan He, Wei-Yan You and Jun Gao
    Citation: Molecular Brain 2023 16:22
    Content type: Research Published on:

  48. Electromagnetic pulse (EMP), a unique type of electromagnetic radiation, may induce diverse neuropsychiatric disorders, such as irritability, hyperkinesis, retardation of learning and memory. However, the unde...

    Authors: Xia-Jing Zhang, Zhi-Bin Xiao, Jun-Xiang Gu, Kun Chen, Jian Wang, Sheng-Long Xu, Ke-Ke Xing and Tao Chen
    Citation: Molecular Brain 2023 16:21
    Content type: Research Published on:

  49. NLGN4X was identified as a single causative gene of rare familial nonsyndromic autism for the first time. It encodes the postsynaptic membrane protein Neuroligin4 (NLGN4), the functions and roles of which, howeve...

    Authors: Akie Toya, Masahide Fukada, Eiko Aoki, Tohru Matsuki, Masashi Ueda, Shima Eda, Yoshio Hashizume, Akio Iio, Shigeo Masaki and Atsuo Nakayama
    Citation: Molecular Brain 2023 16:20
    Content type: Research Published on:

  50. A growing body of evidence suggests that intractable pain reduces both the quality of life and survival in cancer patients. In the present study, we evaluated whether chronic pain stimuli could directly affect...

    Authors: Kenichi Tanaka, Takashige Kondo, Michiko Narita, Takeru Muta, Sara Yoshida, Daisuke Sato, Yukari Suda, Yusuke Hamada, Takatsune Shimizu, Naoko Kuzumaki and Minoru Narita
    Citation: Molecular Brain 2023 16:19
    Content type: Research Published on:
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