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  1. Content type: Research

    Microglia have been shown to be of critical importance to the progression of temporal lobe epilepsy. However, the broad transcriptional changes that these cells undergo following seizure induction is not well ...

    Authors: Dale B. Bosco, Jiaying Zheng, Zhiyan Xu, Jiyun Peng, Ukpong B. Eyo, Ke Tang, Cheng Yan, Jun Huang, Lijie Feng, Gongxiong Wu, Jason R. Richardson, Hui Wang and Long-Jun Wu

    Citation: Molecular Brain 2018 11:34

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  2. Content type: Research

    Schizophrenia (SCZ) is a severe mental disorder characterized by delusion, hallucination, and cognitive deficits. We have previously identified from schizophrenia patients a loss-of-function mutation Arg215→His21...

    Authors: Dong-Yun Jiang, Zheng Wu, Cody Tieu Forsyth, Yi Hu, Siu-Pok Yee and Gong Chen

    Citation: Molecular Brain 2018 11:31

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  3. Content type: Research

    Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterized by a selective loss of upper and lower motor neurons. Recent studies have shown that mutations in SQSTM1 are linked to ...

    Authors: Shun Mitsui, Asako Otomo, Masahisa Nozaki, Suzuka Ono, Kai Sato, Ryohei Shirakawa, Hiroaki Adachi, Masashi Aoki, Gen Sobue, Hui-Fang Shang and Shinji Hadano

    Citation: Molecular Brain 2018 11:30

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  4. Content type: Short report

    Alpha-synuclein (α-SYN) is one of the key contributors in Parkinson’s disease (PD) pathogenesis. Despite the fact that increased α-SYN levels are considered one of the key contributors in developing PD, the mo...

    Authors: Goun Je, Subhrangshu Guhathakurta, Seung Pil Yun, Han Seok Ko and Yoon-Seong Kim

    Citation: Molecular Brain 2018 11:29

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  5. Content type: Research

    A high-fat diet (HFD) causes obesity by promoting excessive energy intake, and simultaneously, by disturbing the timing of energy intake. Restoring the feeding pattern is sufficient to prevent HFD-induced obes...

    Authors: Tsutomu Sasaki, Rika Numano, Hiromi Yokota-Hashimoto, Sho Matsui, Naobumi Kimura, Hideyuki Takeuchi and Tadahiro Kitamura

    Citation: Molecular Brain 2018 11:28

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  6. Content type: Research

    Rapgef2 and Rapgef6 define a subfamily of guanine nucleotide exchange factors for Rap small GTPases, characterized by the possession of the Ras/Rap-associating domain. Previous genomic analyses suggested their...

    Authors: Kazuhiro Maeta, Satoko Hattori, Junji Ikutomo, Hironori Edamatsu, Shymaa E. Bilasy, Tsuyoshi Miyakawa and Tohru Kataoka

    Citation: Molecular Brain 2018 11:27

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  7. Content type: Short report

    One of the unmet clinical needs in demyelinating diseases such as Multiple Sclerosis (MS) is to provide therapies that actively enhance the process of myelin regeneration (remyelination) in the central nervous...

    Authors: Marie Dittmer, Andrew Young, Thomas O’Hagan, George Eleftheriadis, Peter Bankhead, Yvonne Dombrowski, Reinhold J. Medina and Denise C. Fitzgerald

    Citation: Molecular Brain 2018 11:25

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  8. Content type: Research

    This study describes the functional interaction between the Cav3.1 and Cav3.2 T-type calcium channels and cytoskeletal spectrin (α/β) and ankyrin B proteins. The interactions were identified utilizing a proteo...

    Authors: Agustin Garcia-Caballero, Fang-Xiong Zhang, Victoria Hodgkinson, Junting Huang, Lina Chen, Ivana A. Souza, Stuart Cain, Jennifer Kass, Sascha Alles, Terrance P. Snutch and Gerald W. Zamponi

    Citation: Molecular Brain 2018 11:24

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  9. Content type: Research

    The trigemino-thalamic (T-T) and trigemino-parabrachial (T-P) pathways are strongly implicated in the sensory-discriminative and affective/emotional aspects of orofacial pain, respectively. These T-T and T-P p...

    Authors: Chun-Kui Zhang, Zhi-Hong Li, Yu Qiao, Ting Zhang, Ya-Cheng Lu, Tao Chen, Yu-Lin Dong, Yun-Qing Li and Jin-Lian Li

    Citation: Molecular Brain 2018 11:22

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  10. Content type: Review

    Neurodegenerative disorders are frequent, incurable diseases characterised by abnormal protein accumulation and progressive neuronal loss. Despite their growing prevalence, the underlying pathomechanism remain...

    Authors: János Bencze, Gábor Miklós Mórotz, Woosung Seo, Viktor Bencs, János Kálmán, Christopher Charles John Miller and Tibor Hortobágyi

    Citation: Molecular Brain 2018 11:20

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  11. Content type: Research

    Morphine tolerance is a challenging clinical problem that limits the use of morphine in pain treatment, but the mechanisms of morphine tolerance remain unclear. Recent research indicates that long noncoding RN...

    Authors: Jiali Shao, Jian Wang, Jiangju Huang, Chang Liu, Yundan Pan, Qulian Guo and Wangyuan Zou

    Citation: Molecular Brain 2018 11:21

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  12. Content type: Short report

    Alzheimer’s disease (AD) is characterized by neurotoxicity mediated by the accumulation of beta amyloid (Aβ) oligomers, causing neuronal loss and progressive cognitive decline. Genetic deletion or chronic phar...

    Authors: Khaled S. Abd-Elrahman, Alison Hamilton, Maryam Vasefi and Stephen S. G. Ferguson

    Citation: Molecular Brain 2018 11:19

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  13. Content type: Research

    Three-dimensional (3D) reconstruction of thick samples using superresolution fluorescence microscopy remains challenging due to high level of background noise and fast photobleaching of fluorescence probes. We...

    Authors: Sangjun Park, Wooyoung Kang, Yeong-Dae Kwon, Jaehoon Shim, Siyong Kim, Bong-Kiun Kaang and Sungchul Hohng

    Citation: Molecular Brain 2018 11:17

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  14. Content type: Research

    Our previous studies demonstrated that vitamin A deficiency (VAD) can impair the postnatal cognitive function of rats by damaging the hippocampus. The present study examined the effects of retinoic acid (RA) o...

    Authors: Wei Jiang, Min Guo, Min Gong, Li Chen, Yang Bi, Yun Zhang, Yuan Shi, Ping Qu, Youxue Liu, Jie Chen and Tingyu Li

    Citation: Molecular Brain 2018 11:14

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  15. Content type: Research

    The transcriptional repressor DREAM (downstream regulatory element antagonist modulator) is a multifunctional neuronal calcium sensor (NCS) that controls Ca2+ and protein homeostasis through gene regulation and p...

    Authors: Alejandro López-Hurtado, Daniel F. Burgos, Paz González, Xose M. Dopazo, Valentina González, Alberto Rábano, Britt Mellström and Jose R. Naranjo

    Citation: Molecular Brain 2018 11:13

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  16. Content type: Research

    The 18 kDa translocator protein (TSPO) is primarily localized in the outer mitochondrial membrane of steroid-synthesizing cells in the central and peripheral nervous systems. One of the protein’s main function...

    Authors: Xu-bo Li, An Liu, Le Yang, Kun Zhang, Yu-mei Wu, Ming-gao Zhao and Shui-bing Liu

    Citation: Molecular Brain 2018 11:12

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  17. Content type: Research

    Neuropathic pain is a complex, chronic pain state characterized by hyperalgesia, allodynia, and spontaneous pain. Accumulating evidence has indicated that the microglial Toll-like receptor 4 (TLR4) and autopha...

    Authors: Yibo Piao, Do Hyeong Gwon, Dong-Wook Kang, Tae Woong Hwang, Nara Shin, Hyeok Hee Kwon, Hyo Jung Shin, Yuhua Yin, Jwa-Jin Kim, Jinpyo Hong, Hyun-Woo Kim, Yonghyun Kim, Sang Ryong Kim, Sang-Ha Oh and Dong Woon Kim

    Citation: Molecular Brain 2018 11:11

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  18. Content type: Research

    Ghrelin exerts a wide range of physiological actions throughout the body and appears to be a promising target for disease therapy. Endogenous ghrelin receptors (GHSRs) are present in extrahypothalamic sites in...

    Authors: Yukari Suda, Naoko Kuzumaki, Takefumi Sone, Michiko Narita, Kenichi Tanaka, Yusuke Hamada, Chizuru Iwasawa, Masahiro Shibasaki, Aya Maekawa, Miri Matsuo, Wado Akamatsu, Nobutaka Hattori, Hideyuki Okano and Minoru Narita

    Citation: Molecular Brain 2018 11:6

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