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Figure 5 | Molecular Brain

Figure 5

From: Induction- and conditioning-protocol dependent involvement of NR2B-containing NMDA receptors in synaptic potentiation and contextual fear memory in the hippocampal CA1 region of rats

Figure 5

NR2B-NMDAR mediated Ca2+ influx under spiking-timing and pairing protocols. A. A representative image showing the CA1 pyramidal neuron filled with OGB-1. ROI, region of interests. B. Raw sample fluorescence images from the ROI before (1), during (2) and after (3) induction of LTP with the spike-timing protocol. Scale bar, 1.0 μm. C. Elevation of Ca2+ signal in the ROI during induction of LTP with the spike-timing protocol (upper). Treatment with ifenprodil (3 μM) reduced the Ca2+ signal (middle). The difference of [Ca2+] signals in control and in the presence of ifenprodil (lower) shows the NR2B-NMDAR mediated Ca2+ influx. D. Elevation of Ca2+ signal in the ROI during induction of LTP with the pairing protocol (upper). Treatment with ifenprodil (3 μM) reduced the Ca2+ signal (middle). The difference of [Ca2+] signals in control and in the presence of ifenprodil (lower) shows the NR2B-NMDAR mediated Ca2+ influx.

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Molecular Brain

ISSN: 1756-6606