Skip to main content
Figure 7 | Molecular Brain

Figure 7

From: Induction- and conditioning-protocol dependent involvement of NR2B-containing NMDA receptors in synaptic potentiation and contextual fear memory in the hippocampal CA1 region of rats

Figure 7

NR2B-NMDARs are required for the retrieval of contextual fear memory induced by both five and one CS-US pairing conditioning. A. Pre-retrieval intra-CA1 inhibition of NR2B- or NR2A-NMDARs impaired the expression of 48-h contextual fear memory induced by the single CS-US pairing protocol (A1). The expression of 48-h auditory fear memory was intact (A2). **p < 0.01 vs. vehicle. B. Pre-retrieval intra-CA1 inhibition of NR2B- or NR2A-NMDARs impaired the expression of 48-h contextual fear memory induced by the five CS-US pairing protocol (B1). The expression of 48-h auditory fear memory was intact (B2). **p < 0.01 vs. vehicle. C. Reconstruction of the infusion sites in the CA1 region. Filled squares: vehicle; Filled circles: NVP-AAM077; Open triangles: ifenprodil; Open circles: Ro25-6981. D. A representative coronal section showing an infusion site of ifenprodil in the CA1 region.

Back to article page

Molecular Brain

ISSN: 1756-6606