Table 1 Effects of ablated neurogenesis on learning and memory.
From: Effect of ablated hippocampal neurogenesis on the formation and extinction of contextual fear memory
Ablation method | Extent of ablation | Behavior task tested | Species (Strain) | Effect | Ref |
|---|---|---|---|---|---|
MAM | ~84% | Trace eye blink conditioning | Rat (Sprague-Dawley) | - | [4] |
|  | ~84% | Delayed eye blink conditioning | Rat (Sprague-Dawley) | · | [4] |
|  | ~75% | Morris water maze | Rat (Sprague-Dawley) | · | [6] |
| Â | ~85% | Trace fear conditioning | Rat (Sprague-Dawley) | - | [6] |
|  | ~85% | Contextual fear memory | Rat (Sprague-Dawley) | · | [6] |
Irradiation | ~85% * | Contextual fear memory | Mouse (129SvEv) | - | [3] |
|  | ~85% * | Cued fear memory, Morris water maze, Y maze | Mouse (129SvEv) | · | [3] |
| Â | ~75% | Radial arm maze (hippocampus dependent) | Mouse (129SvEv) | + | [7] |
|  | ~90% | Morris water maze | Rat (Long Evans) | · | [8] |
| Â | ~90% | Morris water maze (only long-term memory) | Rat (Long Evans) | - | [8] |
Transgenic | ~85% * | Contextual fear memory | Mouse (C57BL6-BALBc mixed) | - | [3] |
|  | ~85% * | Cued fear memory | Mouse (C57BL6-BALBc mixed) | · | [3] |
| Â | ~75% | Radial arm maze (hippocampus dependent) | Mouse (C57BL6-BALBc mixed) | + | [7] |
| Â | N. S. | Barnes maze, Contextual fear memory | Mouse (C57BL/6J) | - | [5] |
|  | N. S. | Cued fear memory | Mouse (C57BL/6J) | · | [5] |
|  | ~66% | Contextual fear memory, Cued fear memory | Mouse (backcrossing to C57BL/6J) | · | [9] |