Figure 4

Effect of inhibitors on various kinases and NMDAR-LTD. The table shows the kinases (listed alphabetically) inhibited by each substance. The red cells depict a strong inhibition (over 66% inhibition), the orange a moderate inhibition (33–66%) and the yellow cells a weak inhibition (less than 33%). These data come from kinase assays performed at the same or a similar concentration as used in our experiments, except for AR-164 and KT5720 for which the kinase selectivity has been evaluated for a concentration 10-fold higher [24, 54–58]. White cells indicate that specificity data are not available. The histogram shows the level of LTD, plotted as a percentage of baseline, for each of the conditions described immediately above. Black bars show a significant difference in LTD magnitude compared to control LTD (either with or without DMSO, as appropriate) and the gray bars show no difference with control.