Figure 4
From: Abnormalities in brain structure and behavior in GSK-3alpha mutant mice
Impaired information processing in GSK-3α KO mice. A-B. Prepulse inhibition of acoustic startle response. A. PPI assay using a combination of startle (120 dB) and three prepulse levels (69 dB, 73 dB, and 81 dB) in GSK-3α KO (n = 11-13), WT (n = 9-10) (each gender). PPI is expressed as the mean percent reduction (± SEM) in startle amplitude at all three prepulses. Higher y axis values represent greater percent PPI. *p ≤ 0.05; **p ≤ 0.001. B. The amplitude of the acoustic startle response was similar between WT and KO. p.value = n.s. C. Latent inhibition. Mean suppression ratios (± SEM) of GSK-3α KO (n = 11-12) and WT (n = 9-12) (both genders). LI deficit was observed in GSK-3α KO group. PE = pre-exposed mice; NPE = non-pre-exposed mice to the CS. ***p ≤ 0.0001 in WT PE vs. NPE.