Table 4 Summary table of behavioral phenotypes of GSK-3α KO mice vs. WT littermate controls
From: Abnormalities in brain structure and behavior in GSK-3alpha mutant mice
Type of behavior | Changes | Type of the test | Figure # |
|---|---|---|---|
Anxiety | â–² in females only | EPM | Table 1 |
≠in males | Light-dark box | Figure 1A-D | |
Emotionality | â–² (both genders) | Open field 5 min | Table 2 |
Locomotor activity | â–¼ | Open field 30 min | Figure 2C |
Exploratory activity | â–¼ | Open field 30 min | Figure 2D |
Depression-like behavior | â–¼ | FST | Figure 2A |
â–¼ | TST | Figure 2B | |
Sociability and social novelty | â–¼ | Social interaction test | Figure 3A |
Aggression | â–¼ | Resident Intruder | Figure 3B |
Information processing | â–² PPI | PPI/ASR | Figure 4A-B |
â–² NPE in KO | LI | Figure 4C | |
Long term memory | â–¼ | FC | Figure 5A-B |
≠| Passive avoidance | Figure 5D | |
Coordination, balance | â–¼ | Rotarod | Figure 7B |
Motor learning | ≠| Rotarod | Figure 7B |
Neuroanatomical changes | â–² cerebellum | MRI | Figure 6 |
â–² brain | Brain weight | Figure 7A | |
â–¼ Purkinje cells | IHC | Figure 7C-E |