Figure 5
From: The transcription factor RBP-J is essential for retinal cell differentiation and lamination
Up-regulation of interneurons differentiation-related genes but decrease of interneurons in Chx10Cre-RBPf/fretinae at embryonic stages. (A-H) Expression of Math3 (A, B), Neurod1 (C, D), Ngn2 (E, F) and Mash1 (G, H) are enhanced in RBP-J deficient retinae (B, D, F, H) compared to wild-type retinae (A, C, E, G) at E13.5. (I-L) Hes1 expression is reduced but Hes5 expression is unchanged in RBP-J deficient retinae (J, L) relative to wild-type controls (I, K). (M-P) NF165-immunoreactive cells and Ptf1a-expressing cells are reduced in RBP-J deficient retina at E16.5 (N, P) compared with wild-type controls (M, O). (Q-X) Expression of Sox2 (Q, R), Pax6 (S, T), CyclinD1 (U, V), and Fgf15 (W, X) are all decreased in RBP-J deficient retinae (R, T, V, X) compared with wide-type controls at E13.5 (Q, S, U, W). Scale bars, A-L, Q-X, 100 μm, M-P, 100 μm.