Figure 2

alpha-CaMKII overexpressing mice exhibit an increase in anxiety-like behaviors. (A, B) The total path length (A) and the percent of time spent in the center (B) the open field test, are shown for alpha-CaMKII overexpressing (n = 10) and WT mice (n = 10). (C, D) The number of entries into the open section (C) and the time spent in the open section (D) in the elevated zero maze test, are shown for alpha-CaMKII (n = 26) and WT mice (n = 13). (E-G) Latency (E), number of transitions (F) and time spent in light box (G) in light/dark transition test, are shown for alpha-CaMKII (n = 13) and WT mice (n = 13). (H) Social interaction time in the social interaction test are shown for alpha-CaMKII (n = 13) and WT mice (n = 12). The asterisk indicates statistical significance at P < 0.05.