Figure 7

Immunoreactivity of TDO in the SVZ, the olfactory bulb, and the cerebellum. A and B: TDO was not stained in the SVZ (A) and the olfactory bulb (OB) (B). The immunoreactivities for TDO in wild type and Tdo-/- mice were background level. C: In the cerebellum, the immunoreactivity for TDO was observed in granule cells and Purkinje cells of wild type mice, but these positive structures disappeared in Tdo-/- mice. The cytoarchitectural organization of Tdo-/- mice was the same as that of wild type mice. E, external plexiform layer; G, granule cell layer; Gm, glomerular layer; I, internal plexiform layer; LV, lateral ventricle; Mi, mitral cell layer; Mo, molecular layer; P, Purkinje cell layer; St, striatum; Su, subependymal zone.