DREAM (Downstream Regulatory Element Antagonist Modulator) contributes to synaptic depression and contextual fear memory

Table 1 Examples of genetic manipulations on hippocampal CA1 LTD and fear memory

Genetic manipulations	CA1 LTP	CA1 LTD	Basal transmission	Contextual fear memory	Auditory fear memory	References
TgDREAM	Normal	Reduced	Normal	Reduced	Normal	This study
SV40 transgenic	Normal	Reduced	Normal	Normal	-	[72]
Neurabin^-/-	Reduced	Normal	Enhanced	Reduced	Normal	[68]
Shank1^-/-	Normal	Normal	Reduced	Reduced	Normal	[76]
MeCP2^308/Y	Reduced	Reduced	Enhanced	Reduced	-	[67]
EGR1^-/-	Normal	Normal	-	Normal	Reduced	[77, 78]
NCX2^-/-	Enhanced	Lower threshold	Normal	Enhanced	Normal	[69]
CaMKIV^-/-	Reduced	Normal	Normal	Reduced	Reduce	[23, 25]
Calcineurin^-/-	Normal	Reduced	Normal	Normal	Normal	[71]
NMDA NR2B overexpression	Enhanced	Normal	Normal	Enhanced	Enhanced	[70]
PKCγ^-/-	Reduced	Normal	Normal	Reduced	Normal	[65, 66]

ISSN: 1756-6606