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Figure 2 | Molecular Brain

Figure 2

From: Chronic treatment with fluoxetine for more than 6 weeks decreases neurogenesis in the subventricular zone of adult mice

Figure 2

Effects of FLX on the numbers of Ki67-positive cells in the DG and the SVZ. (A) Cell proliferation in the DG. Ki67-positive structures, which are the nuclei of proliferating cells, stand in a line between the granule cell layer and the hilus. FLX treatments upregulated Ki67-positive cells in all periods, compared with sham-operated and control pellet-administered mice. (B) Cell proliferation in the SVZ. The numbers of Ki67-positive cells in FLX-treated mice were decreased at 6 and 9 weeks, but not at 3 weeks. The numbers of Ki67-positive cells in the DG (C) and the SVZ (D) are quantified. The values are means ± SEM of 4-5 animals in each group. ** p < 0.01 significantly different from the sham-operated group. Gr, granule cell layer; Hi, hilus; Lv, lateral ventricle; Mo, molecular layer; Se, septum; St, striatum.

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Molecular Brain

ISSN: 1756-6606