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Figure 5 | Molecular Brain

Figure 5

From: Chronic treatment with fluoxetine for more than 6 weeks decreases neurogenesis in the subventricular zone of adult mice

Figure 5

Effects of FLX on the numbers of BrdU- and NeuN-positive cells in the olfactory bulb. (A) 3-week survival of new neurons in the olfactory bulbs of mice treated with FLX for 6 weeks. (B) 3-week survival of new neurons in the olfactory bulbs of mice treated with FLX for 9 weeks. Tissue sections in both A and B were double-stained with anti-BrdU (green) and anti-NeuN (magenta). The higher magnifications of the boxed-in areas in (B) are displayed in (C). (C) High power images of BrdU and NeuN double-positive cells (arrowheads) in the olfactory bulbs in the control (top) and FLX-treated mice (bottom). (D) Quantification of BrdU and NeuN double-positive cells in the olfactory bulb. The values are means ± SEM of 4-5 animals in each group. ** p < 0.01 significantly different from sham-operated group. Ex, external plexiform layer; Gr, granule cell layer; Gm, glomerular layer; Su, subependymal zone.

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Molecular Brain

ISSN: 1756-6606