Figure 6
From: Behavioral destabilization induced by the selective serotonin reuptake inhibitor fluoxetine
Suppression of fluoxetine-induced behavioral destabilization in 5-HT 4 -deficient mice. (A) Averaged data showing home cage activity levels of control and FLX22-treated 5-HT4+/+ mice (n = 9 each). (B) FLX22 increased CV of activity levels during last 2 weeks of treatments in 5-HT4+/+ mice (U = 5, p = 0.0008), but had no significant effect on mean activity levels during the same period (U = 30, p = 0.3865). (C) Averaged data showing home cage activity levels of control and FLX22-treated 5-HT4-/- mice (n = 11 each). (D) FLX22 reduced mean activity levels during last 2 weeks of treatments (z = 2.627, p = 0.0087), but had no significant effect on CV of activity in 5-HT4-/- mice (z = 0.591, p = 0.5546).