Figure 8

Effects of fluoxetine on anxiety- and depression-related behaviors in 5-HT ₄ -deficient mice. (A) FLX22 had no significant effects on the total distance traveled (U = 23, p = 0.3823) or time spent in the center (U = 22, p = 0.3282) in the open field test in 5-HT₄-/- mice (n = 8 each). (B) FLX22 had no significant effects on the total distance traveled (U = 30, p = 0.8785), the number of transition (z = 1.05, p = 0.2786), time spent in the light compartment (z = 0.735, p = 0.4418), or the latency to enter the light compartment (U = 31, p = 0.9591) in the light/dark transition test in 5-HT₄-/- mice (n = 8 each). (C) FLX22 had no significant effects on the total distance traveled (U = 28, p = 0.7209), the total number of entries into arms (z = 0.945, p = 0.3282), time spent on open arms (U = 32, p = 1), or entry into open arms (U = 28, p = 0.7209) in the elevated plus-maze test in 5-HT₄-/- mice (n = 8 each). (D) FLX22 increased immobile time in the forced swim test (n = 8 each, U = 4, p = 0.0019) and decreased immobile time in the tail suspension test in 5-HT₄-/- mice (n = 8 each, U = 7, p = 0.007). Percent values are calculated as in Figure 3 and 5.