Skip to main content
Figure 4 | Molecular Brain

Figure 4

From: si-RNA inhibition of brain insulin or insulin-like growth factor receptors causes developmental cerebellar abnormalities: relevance to fetal alcohol spectrum disorder

Figure 4

Effects of ICV administration of si-RNA targeting insulin or IGF receptors on neurotrophin and neurotrophin receptor expression. Long Evans rat pups were administered ICV injections of si-Scr, si-InR, si-IGF-1R, or si-IGF-2R on P2. Cerebella harvested on P24 were used to measure (A) NGF, (B) BDNF, (C) p75, and (D) NTRK expression by qRT-PCR analysis with results normalized to 18S rRNA. Box plots depict means, 95% confidence intervals, and range for each group. Inter-group statistical comparisons were made using the Kruskal-Wallis one-way ANOVA and the Dunn's multiple comparisons post hoc test. Significant P-values are indicated within the panels.

Back to article page

Molecular Brain

ISSN: 1756-6606