Figure 2
From: A Co-operative Regulation of Neuronal Excitability by UNC-7 Innexin and NCA/NALCN Leak Channel
Tissue specificity of UNC-7 expression for aldicarb phenotype. unc-7(hp121) animals expressing UNC-7 by pan-neuronal (Prgef-1), cholinergic (Pacr-2) and interneuron (Pglr-1) promoters were assayed for aldicarb sensitivity. Representative results of a same-day experiment on the percentage of mobile animals after 240 minutes of aldicarb exposure at indicated concentrations (see Methods, n = 10 animals per strain). Pan-neuronally expressed UNC-7 rescued aldicarb sensitivity, but expression of UNC-7 in cholinergic or interneurons failed to rescue aldicarb sensitivity.