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Table 4 Enhancers of the Pink1-RNAi wing phenotype

From: Genome-wide screen for modifiers of Parkinson's disease genes in Drosophila

Deficiencies

Breakpoints

Strength of modificationa

Df(2L)net-PMF

21A1;21B7-8

++

Df(2L)BSC4

21B7-C1;21C2-3

++

Df(2L)BSC16

21C3-4;21C6-8

++

Df(2L)BSC17

30C3-5;30F1

++

Df(2L)BSC50

30F5;31B1

+++

Df(2R)nap9

42A1-2;42E6-F1

++

Df(2R)cn9

42E;44C

++

Df(2R)BSC29

45D3-4;45F2-6

++

Df(2R)BSC39

48C5-D1;48D5-E1

++

Df(2R)BSC3

48E12-F4;49A11-B6

+++

Df(2R)BSC22

56D7-E3;56F9-12

++

Df(3L)BSC27

65D4-5;65E4-6

++

Df(3L)BSC14

67E3-7;68A2-6

+++

Df(3L)XG5

71C2-3;72B1-C1

+++

Df(3L)ED4782

75F2;76A1

++

Df(3L)HD1

79D3-E1;79F3-6

++

Df(3R)BSC47

83B7-C1;83C6-D1

++

Df(3R)Tpl10

83C1-2;84B1-2

++

  1. Each deficiency was crossed into the Pink1 knockdown background and the wing posture phenotype was scored. Crosses were maintained at 25°C.
  2. a Each '+' represents 1.0 SD from the mean (i.e. ~64.5%) observed for Pink1 RNAi alone flies. Deficiencies that also enhanced park RNAi wing posture phenotype (Table 1) are indicated in bold.