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Figure 3 | Molecular Brain

Figure 3

From: Copy number loss of (src homology 2 domain containing)-transforming protein 2 (SHC2) gene: discordant loss in monozygotic twins and frequent loss in patients with multiple system atrophy

Figure 3

High-density custom-made tiling microarray analysis of the MZ twins discordant for the MSA phenotype. (a) Competitive hybridization of genomic DNA from the MSA-affected twin (HK33) versus that from his twin (HK34). (b) Dye-swap experiment of the normal twin (HK34) versus his affected twin (HK33). (c) Competitive hybridization of genomic DNA from the MSA-affected twin (HK33) versus that from a reference Japanese male (HapMap NA1900). (d) Competitive hybridization of genomic DNA from the MSA-affected twin (HK34) versus that from the reference Japanese male (HapMap NA19000). Each blue line represents a moving average ratio of log2 (Cy5/Cy3). The blue regions indicate deletions; these loci were defined by dye-swap experiments (red region). The top map shows the positions of putative genes in the region [16].

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