Figure 4
From: Differential trafficking of AMPA receptors following activation of NMDA receptors and mGluRs
Analysis of mEPSCs in infected and uninfected cultured hippocampal neurons reveals a selective decrease in mEPSC frequency. A. Representative examples of traces from (i) uninfected neurons, and (ii) SEP-GluA2 infected neurons. Calibration, 20 pA and 1 s. B. Application of DHPG (blue bar) results in a reduced mEPSC frequency in uninfected (black points) and infected (red points) neurons. C. Analysis of mEPSC amplitudes from uninfected neurons suggests that (i) DHPG does not affect mean amplitudes during or 30 min after DHPG application, and (ii) does not affect the cumulative probability distribution at the same time points. D. Analysis of mEPSC amplitudes from SEP-GluA2 infected neurons suggests that (i) DHPG does not affect mean amplitudes during or 30 min after DHPG application, and (ii) does not affect the cumulative probability distribution at the same time points. Data are presented as mean ± SEM.