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Figure 2 | Molecular Brain

Figure 2

From: Activation of protease activated receptor 1 increases the excitability of the dentate granule neurons of hippocampus

Figure 2

PAR1 activation induces increase in intracellular [Ca2+] in a subpopulation of acutely dissociated dentate neurons, as well as non-neuronal cells. A) Microphotographs of acutely dissociated cells from the dentate gyrus; scale bar is 10 μm. B) Ca2+ imaging traces for cell #0, #4, and #19 as shown in A. Cells were exposed to 30 μM TFLLR and 100 μM NMDA at the indicated times. Y axis indicates intensity of changes in pixel changes. C) Total percentages of responsive cells are expressed as percent of total cells. D) The response to NMDA was used to categorize the cell as neuronal or non-neuronal. The bar graph indicates the percent of TFLLR-responsive cells expressed as percent of total number of neurons or non-neurons. This experiment was performed from five different mice.

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Molecular Brain

ISSN: 1756-6606