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Table 1 Statistical comparison of geometric spine measurements

From: Automated 4D analysis of dendritic spine morphology: applications to stimulus-induced spine remodeling and pharmacological rescue in a disease model

 

Head width

Neck width

Length

 

Manual

Auto

Manual

Auto

Manual

Auto

Neurons

      

   Mean (μm)

0.67

0.40

0.27

0.17

1.91

1.73

   SD

±0.22

±0.08

±0.07

±0.03

±0.73

±0.26

   CV

0.32

0.20

0.27

0.20

0.38

0.15

Spines

      

   Median (μm)

0.60

0.44

0.23

0.11

1.50

1.33

   Range (μm)

2.36

0.79

1.50

0.57

4.60

4.85

   Skewness

1.25

0.10

2.66

2.09

1.03

0.84

  1. The mean, standard deviation (SD), and coefficient of variation (CV) were calculated for the manual and automated measurements of average spine head width, neck width, and length per neuron (μm; N = 28 neurons). The median, range, and skewness were calculated for the distributions of spine head width, neck width, and length determined using the manual (N = 411 spines) and automated methods (N = 423 spines) on the same 28 neurons.
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Molecular Brain

ISSN: 1756-6606