Figure 5
From: Properties of Contextual Memory Formed in the Absence of αCaMKII Autophosphorylation
Normal remote contextual and cued fear LTM after five conditioning trials in αCaMKII autophosphorylation-deficient mice. Means ± s.e.m. are shown. a: WT mice (n = 14) and αCaMKIIT286A mutants (n = 14) were trained with five tone-shock pairings and tested for recent contextual LTM 24 hours after conditioning. Freezing did not differ between the genotypes. b: Thirty days after training the αCaMKIIT286A mutants had normal remote contextual LTM as freezing did not differ between the genotypes, suggesting that the contextual LTM was stable. c: Forty-eight hours after training cued fear LTM was normal as both genotypes showed a similar significant increase in freezing when the tone was presented. d: The cued fear LTM was stable as 31 days after training mice of both genotypes still showed a similar significant increase in freezing when the tone was presented. **, P < 0.01.