Figure 3
From: The spinal notch signaling pathway plays a pivotal role in the development of neuropathic pain
DAPT inhibits thermal hyperalgesia and mechanical allodynia induced by CCI and SNI. (A) Immunostaining revealed that the increase of NICD expression in the spinal cord after nerve injury was significantly inhibited by injection with DAPT. Scale bar, 100 μm. (B) Intrathecal (i.t.) administration of DAPT inhibits thermal hyperalgesia and mechanical allodynia 7 days after CCI. (n = 10). (C) Intrathecal (i.t.) DAPT inhibits mechanical allodynia after SNI in a dose-dependent manner. * P < 0.05, ** P < 0.01, *** P < 0.01 versus SNI rats treated with vehicle (mean ± s.e.m., two-way ANOVA with a post hoc Bonferroni’s test, n = 15).