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Figure 3 | Molecular Brain

Figure 3

From: Distinct mechanisms of axonal globule formation in mice expressing human wild type α-synuclein or dementia with Lewy bodies-linked P123H ß-synuclein

Figure 3

Localization of mitochondrial marker proteins in αS-globules and P123H ßS-globules . Because P123H βS-immunopositive globules in brains of P123H βS tg mice were immunopositive for αS (~100%), double immunofluorescence analyses of αS tg mice (twelve left panels) and P123H ßS tg mice (nine right panels) were performed using αS as a globule identification. In αS tg mice, cytochrome C (upper panels) and HSP60 (lowest panels) showed punctate patterns, while VDAC1 (third panels) was located diffusely. In contrast, COX IV (second panels) was not detected. In P123H βS tg mice, cytochrome C (upper panels), COX IV (middle panels) and VDAC1 (lower panels) were all immunonegative. Representative images are shown for the thalamus in αS tg mice and the basal ganglia in P123H βS tg mice. Scale bar = 5 μm.

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Molecular Brain

ISSN: 1756-6606