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Figure 4 | Molecular Brain

Figure 4

From: Distinct mechanisms of axonal globule formation in mice expressing human wild type α-synuclein or dementia with Lewy bodies-linked P123H ß-synuclein

Figure 4

Characterization of αS modification and oxidative stress for αS-globules and P123H ßS-globules . (a) Double immunofluorescence analyses of αS tg mice (nine left panels) and P123H ßS tg mice (nine right panels) were performed using αS as a globule identification. Phosphorylation of αS, nitration of αS, and 4-HNE staining occurred to different extents in the two types of mice. Representative images are shown for the basal ganglia and thalamus in αS tg mice and for the basal ganglia in P123H βS tg mice. Scale bar = 5 μm. (b) Quantification of data for phosphorylation of αS, nitration of αS, and 4-HNE in the basal ganglia. (n = 3-4, over 18 mo).

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Molecular Brain

ISSN: 1756-6606