Figure 7
From: Rapid synaptic potentiation within the anterior cingulate cortex mediates trace fear learning
Rapid AMPAR upregulation contributes to trace fear learning. During trace fear conditioning, Ca2+ influx via NMDARs initiates AMPAR upregulation through activation of Ca2+/calmodulin-dependent protein kinase IV (CaMKIV) related pathways. Newly recruited postsynaptic AMPARs help potentiate glutamatergic excitatory transmission within the ACC, establishing plasticity in neuronal populations for long term memory storage.