Figure 3

Impaired social recognition memory in dnRAR mice and its rescue by stronger training. (A) STM formed by training for 1.5 min (WT, n = 14; H06, n = 15). Recognition index (left panel). *p < 0.05, compared with WT. Investigation time (right panel). *p < 0.05, compared with training. (B) STM formed by training for 3 min (WT, n = 8; H06, n = 10). Recognition index (left panel). *p < 0.05, compared with WT. Investigation time (right panel). *p < 0.05, compared with training. (C) LTM formed by training for 3 min (WT, n = 28; OFF/ON, n = 26; OFF, n = 17). Recognition index (left panel). *p < 0.05, compared with the other groups. Investigation time (right panel). *p < 0.05, compared with training. (D) LTM formed by massed or spaced training (0 min: WT, n = 11; H06, n = 13; 10 min: WT, n = 12; H06, n = 11; 1 h: WT, n = 17; H06, n = 11). Recognition index (left panel). *p < 0.05, compared with the other groups. Investigation time (right panel). *p < 0.05, compared with the first exposure during training. (E) LTM formed by training for 3 min in WT (n = 11) and dnRAR H02 (n = 13) mice. Recognition index (left panel). *p < 0.05. Investigation time (right panel). *p < 0.05, compared with training. Error bars indicate SEM.