Figure 5

Impaired social recognition memory by the pharmacological inhibition of hippocampal RARα. Recognition index (left panel). Effects of micro-infused Ro41-5253 (Ro41; 242 pg/side) into the dorsal hippocampus at 1, 4, or 24 h before training and the effects of micro-infused low-dose Ro41 (24 pg/side) on 24 h LT-social recognition memory (VEH, n = 38; 1 h, n = 12; 4 h-low, n = 11; 4 h, n = 13; 24 h, n = 12). *p < 0.05, compared with the VEH group. Investigation time (right panel). *p < 0.05, compared with training. The lower panel indicates cannula tip placement in mice infused with VEH or Ro41.