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Table 1 Current densities and voltage-dependent properties of A39V-Cav1.2 without Cavβ, with Cavβ2b, or with Cavβ1b

From: The Brugada syndrome mutation A39V does not affect surface expression of neuronal rat Cav1.2 channels

  Current Density (pA/pF) V1/2 Activation (mV) Slope of Activation (mV) V1/2 Steady State Inactivation (mV) Slope of Steady State Inactivation (mV)
Cav1.2 + Cavα2δ -4.4 +/- 0.5 -9.1 +/- 1.3 4.7 +/- 0.7 -5.4 +/-1.8 6.9 +/- 0.6#
A39V-Cav.2 + Cavα2δ -3.3 +/- 0.5 -11.7 +/- 1.5 4.6 +/- 0.9 -7.3 +/- 1.9 11.8 +/- 1.4#
Cav1.2 + α2δ + Cavβ2b -9.1 +/- 1.4 * -3.8 +/- 0.8 10.2 +/- 1.4 -7.1 +/- 1.7 11.1 +/- 1.8
A39V-Cav1.2 + Cavα2δ + Cavβ2b -9.5 +/- 1.3 ** -3.0 +/- 1.4 13.0 +/- 2.0 -5.2 +/- 2.8 11.5 +/- 1.2
Cav1.2 + Cavα2δ + Cavβ1b -10.6 +/- 1.1 * -9.0 +/- 0.8 8.8 +/- 1.2 -6.3 +/- 1.1 8.4 +/- 1.2
A39V-Cav1.2 + Cavα2δ + Cavβ1b -8.3 +/- 1.0 ** -6.4 +/- 1.1 8.1 +/- 0.9 -6.8 +/- 1.6 9.3 +/- 0.8
  1. - * indicates significant increase in current density when compared to Cav1.2 without a Cavβ subunit; p = < 0.05, ANOVA
  2. - ** indicates significant increase in current density when compared to A39V-Cav1.2 without a Cavβ subunit; p = < 0.05, ANOVA
  3. - Data expressed as mean +/- SEM. Current density was determined from a minimum of 24 cells per condition, from three separate transfections. All other values determined from aforementioned cells which fit the modified Boltzmann, or Boltzmann equations (> 11 cells/per condition)
  4. - # indicates significant difference in slope of steady state inactivation; p = > 0.01, Students T-test