Table 1 Basic channel properties, activators and inhibitors of ASICs

ASIC1

(ACCN2)

ASIC1a

6.2–6.8

MitTx (9.4 nM)

PcTx1 (~1 nM)

Na⁺ > Ca²⁺

[5, 12, 13, 22–27]

Mambalgin (55 nM)

Sevanol (2.2 mM)

A-317567 (2 μM)

ASIC1b

~6.0 (mouse)

MitTx (23 nM)

Mambalgin (192 nM)

mouse: Na⁺ human: Na⁺ > Ca²⁺

[6, 7, 12, 13, 22, 24, 28]

~6.2 (human)

ASIC2 (ACCN1)

ASIC2a

4.5–4.9

Minimal activa-tion by MitTx

A-317567 (29 μM)

Na⁺

[12, 15, 22, 25, 29–31]

ASIC2b

N/A

--

[29–31]

ASIC3

ASIC3

~6.6

GMQ (0.35 mM)

APETx2 (63 nM)

Na⁺

[13, 22, 25, 32–36]

MitTx (830 nM)

Sevanol (0.35 mM)

A-317567 (9.5 μM)

ASIC4

ASIC4

N/A

--

[37]

Heteromeric channels

1a + 1b

6.0

Mambalgin (72 nM)

Na⁺

[15]

1a + 2a

5.5–6.1

Mambalgin (246 nM)

Na⁺

[12, 15, 24, 26]

1a + 2b

Same as ASIC1a

Mambalgin (61 nM) PcTx1 (~3 nM)

Na⁺ > Ca²⁺

[9, 15, 24]

1a + 3

6.3–6,6

Na⁺

[12, 15]

1b + 3

6.0

Na⁺

[15]

1b + 2a

4.9

Na⁺

[15]

2a + 3

5.7–6.1

Na⁺

[12, 15]

2b + 3

6.5

APETx2 (117 nM)

Na⁺

[15, 33, 36]