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Figure 7 | Molecular Brain

Figure 7

From: The long non-coding RNA nuclear-enriched abundant transcript 1_2 induces paraspeckle formation in the motor neuron during the early phase of amyotrophic lateral sclerosis

Figure 7

Scheme of the pathological alterations in the nucleus of an ALS motor neuron. NEAT1_2 expression is induced by ALS-associated mechanisms. NEAT1_2 lncRNA forms paraspeckle structure around IGAZ with NEAT1_1 RNA, RNA-binding proteins consisting of TDP-43 and FUS/TLS, and other paraspeckle proteins including p54nrb, PSF, PSP1 and RNA polymerase II. The right panel represents enlarged illustration of the nucleus of a motor neuron at an early stage of ALS. PS, paraspeckle; I, inosine at an A-to-I RNA editing site.

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Molecular Brain

ISSN: 1756-6606