GluN2B antagonist HON0001 rescues RGCs death in GLAST-deficient mice. (A) Representative photos of wild-type (WT), saline- (GLAST−/−) or HON0001- (GLAST−/− + HON0001) treated retinas. HON0001 (10 mg/kg) or saline were injected orally (p.o.) into GLAST−/− mice from P21 to P35. The animals were killed at P35 after HON0001/saline treatment. Scale bar, 100 μm. (B) Quantification of the cell number in the GCL. The data are presented as mean ± S.E.M. of 4 (WT and GLAST−/−) and 6 (GLAST−/− + HON0001) samples for each experiment. *P <0.05, **P <0.01. GCL, ganglion cell layer; INL, inner nuclear layer; ONL, outer nuclear layer.