A Single injection of the mGlu5 receptor PAM, VU0360172, causes a short-lasting improvement of motor performance in symptomatic SCA1 mice. Motor performance on the rotarod in SCA1 mice with severe motor impairment treated with a single injection of VU0360172 is shown. In (A), values are means ± S.E.M. of 5 mice per group. *p < 0.05 vs. the corresponding values at time 0; Two-way ANOVA for repeated measures + Fisher’s LSD; F(3,12) = 5.921, F(3,12) = 5.629 for time and time x treatment, respectively. In (B), values are means ± S.E.M. of 4 mice per group.