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Table 1 Demographic and clinical data of HD patients

From: Changes of peripheral TGF-β1 depend on monocytes-derived macrophages in Huntington disease

  Number (M,F) Age (24-77 yrs) TFC (13–0) CAG repeats[2743] AO [16-69] HD DI (yrs)[40, 41] DB (108–759) DS (100–0) UHDRS1 (1–100) UHDRS2 (248–7) UHDRS3 (0–88) UHDRS4 (0–25) MMSE (0–30)
Pre-HD 14 35,4 ± 4,4 13 44,0 ± 2,4 - -13,8 ± 7,9 296,9 ± 70,8 99,7 ± 0,9 5,8 ± 4,3 278,3 ± 33,1 6,2 ± 6,9 25,0 ± 0,0 27,8 ± 1,3
(M = 8, F = 6)
I HD 15 (M = 9, F = 6) 46,9 ± 8,4 11,8 ± 1,1 44,1 ± 2,2 44,2 ± 8,1 -1,6 ± 6,2 389,5 ± 70,2 92,1 ± 4,1 24,1 ± 7,9 186,6 ± 54,1 16,5 ± 7,5 23,7 ± 1,7 26,9 ± 1,7
II HD 36 (M = 17, F = 19) 55,4 ± 10,9 7,7 ± 0,8 43,2 ± 3,0 47,1 ± 10,3 3,9 ± 10,3 403,8 ± 124,1 77,2 ± 6,3 39,3 ± 12,2 132,2 ± 52 19,7 ± 7,9 17,6 ± 4,2 23,3 ± 4,5
III HD 31 (M = 18, F = 13) 53,6 ± 11,7 4,6 ± 1,3 44,5 ± 3,5 44,1 ± 10,1 6,7 ± 6,7 448,8 ± 110,1 61,3 ± 11,6 55,4 ± 12,8 89,1 ± 48,8 23,4 ± 10,0 9,8 ± 5,1 20,2 ± 5,0
IV HD 10 (M = 4, F = 6) 59,2 ± 10,5 1,6 ± 0,5 44,0 ± 3,6 46,4 ± 10,2 11,7 ± 6,1 470,7 ± 128,0 39,0 ± 8,4 75,8 ± 21,4 71,2 ± 44,9 23,3 ± 14,2 1,3 ± 0,8 21,0 ± 5,1
V HD 6 (M = 2, F = 4) 58,3 ± 13,4 0 45,0 ± 5,3 41,0 ± 15,6 10,3 ± 5,9 499,5 ± 127,0 22,9 ± 6,4 90,2 ± 13,4 - 15,0 ± 6,0 0,2 ± 0,4 11,4 ± 3,0
  1. Control subjects are 46 (M = 19, F = 27; mean age: 49,3 ±10,7). Values are given as mean ± s.d.
  2. yrs: years; TFC: total functional capacity; AO: age at onset; HD DI: Huntington Disease Development Index; DB: Disease Burden; DS: Diasability.
  3. Score; UHDRS: Unified Huntington Disease Rating Scale; MMSE: Mini Mental State Examination.