Figure 6

TAT-α7pep2 Peptide treatment affected nonspatial learning and memory. TAT-α7pep2 Peptide treatment impaies novel object recognition (A) but not displaced object recognition (B). Times of exploration of the DO and NDO were recorded and expressed as a percentage of the total time of objects investigated. In the novel object recognition session, one of the familiar NDOs was replaced with a new object (NO) at the same location and the two familiar DOs were removed. Data were analyzed with ANOVA with treatment as a between-subjects factor, and object rearrangement or object replacement as a repeated measures factor. The Tukey test was used for post hoc comparisons when ANOVA yielded statistically significant main effects or interactions. (C) In the elevated plus maze, no significant changes in the percent of time spent in open arms, entries into the open arms and head dips were observed in different treatment groups.