Figure 9

ATX partially reverses a time-dependent deceleration of spike propagation on the main axons of cerebellar Purkinje cells. A ~ B) shows spikes on axons (top traces) and dV/dt of somatic spikes (bottom traces) in initial (red), middle (green) and late phases (blue) under the conditions of control (A) and ATX (B). Traces in different colors are taken from boxes in 8A ~ B with corresponding colors. C) illustrates the normalized velocity of spike propagation vs. time at 200 Hz of sequential spikes under the control. Spike propagation velocity decreases to two levels, level one (blue dash line) and two (purple). Red vertical bars show time point of spike propagation failure. D) shows the normalized velocity of spike propagation versus time at 200 Hz of spikes when ATX is given. The deceleration of spike propagation is partially reversed from level two to level one. E) illustrates the normalized velocity of spike propagation versus somatic spiking time under the conditions of control (black symbols) and ATX (reds; an asterisk, p < 0.05, n = 8).