Figure 2

Arc is transcribed during both former and latter parts of extinction training. (A) The Extinction group underwent contextual fear conditioning and extinction training, in which they were re-exposed to the conditioning context for 35 min without shock. The No Extinction group underwent fear conditioning but not extinction training. (B) Representative images of Arc-positive cells in the Extinction and No Extinction groups, respectively. (C) The Extinction group demonstrated more cytoplasmic and nuclear Arc-positive cells relative to the No Extinction group in the BLA (Extinction, n = 5 mice; No Extinction, n = 9 mice, **p < 0.01).