Comprehensive behavioral study of mGluR3 knockout mice: implication in schizophrenia related endophenotypes

Table 1 Comprehensive behavioral test battery and the phenotypes of mGluR3 KO mice

Tests	Phenotypes	Figures	Testing order
General health			1
Whisker, coat, reflexes	-	N/A
Somatic parameters			1
Body weight	↓	Additional file1: Figure S1a
Rectal temperature	-	Additional file1: Figure S1b
Grip strength	-	Additional file1: Figure S1c
Wire-hanging time	-	Additional file1: Figure S1d
Light/dark transition
Anxiety	-	Figure 2e-h	2
Open field
Exploratory locomotion	↑	Figure 2a-d	3
Elevated plus maze
Anxiety	-	Additional file2: Figure S2	4
Hot plate
Pain sensitivity	-	Additional file8: Figure S8	5
Social interaction test in a novel environment
Sociability	-	Additional file3: Figure S3	6
Rotarod
Motor coordination	-	Not shown	7
Prepulse inhibition
Sensorimotor gating	-	Additional file5: Figure S5	8
Porsolt forced swim
Immobility time (behavioral despair)	↓	Figure 5	9
Gait analysis
Gait ataxia	-	Additional file4: Figure S4	10
Barnes maze
Spacial memory	-	Additional file6: Figure S6	11
T-maze forced alternation task
Working memory	↓	Figure 4	12
Cued and contextual fear conditioning
Contextual fear memory	↓	Figure 6	13
Tail suspension
Immobility time (behavioral despair)	-	Not shown	14
24-hour homecage monitoring
Locomotor activity	↑	Figure 3	15
Passive avoidance
Fear memory	-	Additional file7: Figure S7	16

-, No significant differences between WT and KO; ↑, Higher in KO than in WT; ↓, Lower in KO than in WT. The testing order was indicated in the right column.
Rotarod test and tail suspension test were performed according to published methods[21].

ISSN: 1756-6606