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Table 1 Comprehensive behavioral test battery and the phenotypes of mGluR3 KO mice

From: Comprehensive behavioral study of mGluR3 knockout mice: implication in schizophrenia related endophenotypes

Tests Phenotypes Figures Testing order
General health    1
 Whisker, coat, reflexes - N/A  
Somatic parameters    1
 Body weight Additional file1: Figure S1a  
 Rectal temperature - Additional file1: Figure S1b  
 Grip strength - Additional file1: Figure S1c  
 Wire-hanging time - Additional file1: Figure S1d  
Light/dark transition    
 Anxiety - Figure 2e-h 2
Open field    
 Exploratory locomotion Figure 2a-d 3
Elevated plus maze    
 Anxiety - Additional file2: Figure S2 4
Hot plate    
 Pain sensitivity - Additional file8: Figure S8 5
Social interaction test in a novel environment    
 Sociability - Additional file3: Figure S3 6
 Motor coordination - Not shown 7
Prepulse inhibition    
 Sensorimotor gating - Additional file5: Figure S5 8
Porsolt forced swim    
 Immobility time (behavioral despair) Figure 5 9
Gait analysis    
 Gait ataxia - Additional file4: Figure S4 10
Barnes maze    
 Spacial memory - Additional file6: Figure S6 11
T-maze forced alternation task    
 Working memory Figure 4 12
Cued and contextual fear conditioning    
 Contextual fear memory Figure 6 13
Tail suspension    
 Immobility time (behavioral despair) - Not shown 14
24-hour homecage monitoring    
 Locomotor activity Figure 3 15
Passive avoidance    
 Fear memory - Additional file7: Figure S7 16
  1. -, No significant differences between WT and KO; ↑, Higher in KO than in WT; ↓, Lower in KO than in WT. The testing order was indicated in the right column.
  2. Rotarod test and tail suspension test were performed according to published methods[21].