Figure 2

The ambient GABA is similar in LA from control and CIS mice. A, Representative traces showing GABA_AR currents in an outside-out patch evoked by a short-lasting tetanus applied to the LA of control (left) and CIS mice (right). Slices were consecutively perfused with ACSF (top), SKF 89976A (middle) and BIC (bottom). Note that SKF 89976A enhanced the GABA_AR currents in both mice. The stimulus artifacts were truncated for clarity. B-C, Comparisons of the increased amplitude (B) and charge transfer (C) of GABA_AR currents by SKF 89976A in control and CIS mice.