The loss of tonic GABA
R currents in response to chronic immobilization stress (CIS) is mediated by corticosterone (CORT) production with subsequent activation of glucocorticoid receptor. A, Experimental procedures used to treat CIS mice with different drugs to examine the role of CORT signaling in the altered tonic GABAAR currents by CIS. B, Example traces showing the tonic GABAAR currents in LA from CIS mice receiving vehicle pretreatment or pretreated with metyrapone, RU 38486 and spironolactone respectively. C, Summary of the tonic GABAAR currents in (B). D, Comparisons of the plasma CORT levels in control mice and mice having 1 or 10 days recovery from CIS. E, Example traces showing the tonic GABAAR currents in control mice and mice fed with different levels of CORT. F, Summary of the tonic GABAAR currents in (d). *p < 0.05; **p < 0.01.