Figure 5
Effects of synaptotagmin I on the kinetics of Kv4 family subunits expressed in HEK293T cells. (A) Representative current traces of Kv4.1 channel and kv4.1/synaptotagmin I (left), their averaged inactivation time constants (Ï„inact) (middle) and their activation curves; Current amplitudes recorded were normalized to the maximal responses at +30Â mV and plotted as a function of the membrane potential (right). (B) Representative current traces of Kv4.2 channel and kv4.2/synaptotagmin I (left), their averaged Ï„inact (middle) and their activation curves; Current amplitudes recorded were normalized to the maximal responses at +30Â mV and plotted as a function of the membrane potential (right). (C) Representative current traces of Kv4.3 channel and Kv4.3/synaptotagmin I (left), their averaged Ï„inact (middle) and their activation curves; Current amplitudes recorded were normalized to the maximal responses at +30Â mV and plotted as a function of the membrane potential (right).