Skip to main content


Figure 6 | Molecular Brain

Figure 6

From: Synaptotagmin I delays the fast inactivation of Kv1.4 channel through interaction with its N-terminus

Figure 6

Effect of synaptotagmin I on the kinetics of Kv1.4ΔN. (A) Representative traces of Kv1.4ΔN currents expressed alone. (B) Representative traces of Kv1.4ΔN currents coexpressed with synaptotagmin I. Currents were elicited by depolarizing steps from -80 to +70 mV in 10 mV increments every 45 s from a holding potential of -80 mV. (C) Currents recorded upon depolarization to +30 mV. (D) Inactivation time constants (τinact) of the indicated channel obtained at +30 mV. Data are mean ± SD of nine experiments. (E) Activation curves of Kv1.4ΔN and Kv1.4ΔN/synaptotagmin I. Current amplitudes recorded were normalized to the maximal response at +30 mV and plotted as a function of the membrane potential.

Back to article page